Abstract
The objective of this study was to examine placentas after delivery from normal, healthy patients at term gestation. The placentas were from elective cesarean sections (n = 10, prior to the onset of labor) and spontaneous vaginal delivery (n = 10, after labor). We found that deoxyribonucleic acid laddering was present in all placentas and consistent with the pattern found in tissues that undergo apoptosis. Paraffin-embedded sections of placental villi stained by the in situ terminal deoxynucleotidyl transferase mediated biotinylated dUTP nick end labeling method revealed positive apoptotic nuclei in the placental villi. Reverse-transcriptase polymerase chain reaction demonstrated expression of messenger RNA for testosterone-repressed prostate message 2 and B cell lymphoma/leukemia-2 in the placenta. Our data demonstrate that apoptosis occurs in human term placenta. Copyright (C) 2000 S. Karger AG, Basel.
Original language | English (US) |
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Pages (from-to) | 88-91 |
Number of pages | 4 |
Journal | Gynecologic and Obstetric Investigation |
Volume | 50 |
Issue number | 2 |
DOIs | |
State | Published - Jan 1 2000 |
Keywords
- Apoptosis
- B cell lymphoma/leukemia 2 mRNA
- Term placenta
- Testosterone- repressed prostate message 2 mRNA
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology