Apoptosis in human retinal degenerations

X. Ge-Zhi, W. W.Y. Li, M. O.M. Tso, A. H. Friedman

Research output: Contribution to journalArticlepeer-review

80 Scopus citations


Purpose: This paper examined the role of apoptosis in human retinal degenerations including pathologic myopia, age-related macular degeneration, serous retinal detachment, retinal lattice, and paving stone degenerations. Method: Thirty-seven enucleated human eyes with 1 of the above-mentioned retinal degenerations were studied by histopathology and by TdT mediated biotin-dUTP nicked-end labelling (TUNEL) technique. Results: Tunnel labelling characteristic DNA fragmentation of apoptosis was observed in photoreceptor cells in 2 of the 4 eyes with pathologic myopia and in 4 of 16 eyes with age- related macular degeneration, 2 of which were exudative and 2 of which were atrophic. However, only a few scattered photoreceptor cells were labelled in 4 of 8 eyes with serous retinal detachment secondary to malignant melanoma of the choroid. Moreover, non of the photoreceptor cells in the 4 eyes with retinal lattice degeneration and 6 eyes with retinal paving stone degeneration were labelled. Conclusions: Apoptosis is 1 of the important pathways of photoreceptor cell degeneration in pathologic myopia and age- related macular degeneration.

Original languageEnglish (US)
Pages (from-to)411-431
Number of pages21
JournalTransactions of the American Ophthalmological Society
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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