Apolipoprotein E ε4 and tardive dyskinesia in a Japanese population

Takemi Kimura, Masahiro Shono, Shuzo Yokota, Koko Ishizuka, Masafumi Watanabe, Junichi Takamatsu, Taihei Miyakawa

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The findings that free radicals play a causative role in the occurrence of tardive dyskinesia (TD) and that apolipoprotein E (ApoE) 4 has decreased anti-oxidant activity suggest a potential link between TD and ApoE alleles. We, therefore, examined ApoE allelic frequencies in schizophrenic subjects with TD and non-TD. Serum samples were obtained from 333 DSM IV-diagnosed schizophrenic patients and 191 controls in Japan. The presence of TD was evaluated by research diagnostic criteria for TD. ApoE phenotypes of the serum samples were determined by polyacrylamide gel isoelectricfocusing. A total of 62 TD subjects (31 males, 31 females) were identified among all patients examined. No significant differences in ApoE allelic frequency were found between TD and non-TD groups. ApoE ε4 allele frequency, however, was significantly lower in the female TD group than in the male TD group. These findings do not clearly demonstrate a certain association between TD and the ε4 allele, but may preliminarily reveal a difference in influence of this allele on the development of TD between males and females. Copyright (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)329-332
Number of pages4
JournalJournal of Psychiatric Research
Issue number4-5
StatePublished - 2000
Externally publishedYes


  • Apolipoprotein E
  • Free radicals
  • Gender difference
  • Japanese
  • Tardive dyskinesia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


Dive into the research topics of 'Apolipoprotein E ε4 and tardive dyskinesia in a Japanese population'. Together they form a unique fingerprint.

Cite this