Apolipoprotein E polymorphism in the Greek population

Ekaterini Sklavounou; Effrosini Economou-Petersen; Georgia Karadima; Marios Panas; Dimitris Avramopoulos; Angeliki Varsou; Dimitris Vassilopoulos; Michael B. Petersen

doi:10.1111/j.1399-0004.1997.tb02550.x

Apolipoprotein E polymorphism in the Greek population

Ekaterini Sklavounou, Effrosini Economou-Petersen, Georgia Karadima, Marios Panas, Dimitris Avramopoulos, Angeliki Varsou, Dimitris Vassilopoulos, Michael B. Petersen

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The APOE gene is located on chromosome 19, and the three common alleles are designated ε2, ε3, and ε4. The ε4 allele is associated with increased plasma cholesterol, atherosclerosis and cardiovascular disease, Alzheimer's disease, and decreased longevity. The objective of the present study was to estimate the distribution of APOE alleles in the Greek population by DNA analysis. The material consisted of 216 voluntary, healthy Creek blood donors (146 males/70 females). The APOE allele frequencies were ε2: 5.3%, ε3: 88.2%, ε4: 6.5%. The ε4 allele frequency of 6.5% in the Greek population is, together with the frequency in the Chinese population, among the lowest in the world.

Original language	English (US)
Pages (from-to)	216-218
Number of pages	3
Journal	Clinical Genetics
Volume	52
Issue number	4
DOIs	https://doi.org/10.1111/j.1399-0004.1997.tb02550.x
State	Published - Oct 1997
Externally published	Yes

Keywords

Apolipoprotein E
DNA polymorphism
Greek population
Population genetics

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1111/j.1399-0004.1997.tb02550.x

Cite this

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title = "Apolipoprotein E polymorphism in the Greek population",

abstract = "The APOE gene is located on chromosome 19, and the three common alleles are designated ε2, ε3, and ε4. The ε4 allele is associated with increased plasma cholesterol, atherosclerosis and cardiovascular disease, Alzheimer's disease, and decreased longevity. The objective of the present study was to estimate the distribution of APOE alleles in the Greek population by DNA analysis. The material consisted of 216 voluntary, healthy Creek blood donors (146 males/70 females). The APOE allele frequencies were ε2: 5.3%, ε3: 88.2%, ε4: 6.5%. The ε4 allele frequency of 6.5% in the Greek population is, together with the frequency in the Chinese population, among the lowest in the world.",

keywords = "Apolipoprotein E, DNA polymorphism, Greek population, Population genetics",

author = "Ekaterini Sklavounou and Effrosini Economou-Petersen and Georgia Karadima and Marios Panas and Dimitris Avramopoulos and Angeliki Varsou and Dimitris Vassilopoulos and Petersen, {Michael B.}",

year = "1997",

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doi = "10.1111/j.1399-0004.1997.tb02550.x",

language = "English (US)",

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TY - JOUR

T1 - Apolipoprotein E polymorphism in the Greek population

AU - Sklavounou, Ekaterini

AU - Economou-Petersen, Effrosini

AU - Karadima, Georgia

AU - Panas, Marios

AU - Avramopoulos, Dimitris

AU - Varsou, Angeliki

AU - Vassilopoulos, Dimitris

AU - Petersen, Michael B.

PY - 1997/10

Y1 - 1997/10

N2 - The APOE gene is located on chromosome 19, and the three common alleles are designated ε2, ε3, and ε4. The ε4 allele is associated with increased plasma cholesterol, atherosclerosis and cardiovascular disease, Alzheimer's disease, and decreased longevity. The objective of the present study was to estimate the distribution of APOE alleles in the Greek population by DNA analysis. The material consisted of 216 voluntary, healthy Creek blood donors (146 males/70 females). The APOE allele frequencies were ε2: 5.3%, ε3: 88.2%, ε4: 6.5%. The ε4 allele frequency of 6.5% in the Greek population is, together with the frequency in the Chinese population, among the lowest in the world.

AB - The APOE gene is located on chromosome 19, and the three common alleles are designated ε2, ε3, and ε4. The ε4 allele is associated with increased plasma cholesterol, atherosclerosis and cardiovascular disease, Alzheimer's disease, and decreased longevity. The objective of the present study was to estimate the distribution of APOE alleles in the Greek population by DNA analysis. The material consisted of 216 voluntary, healthy Creek blood donors (146 males/70 females). The APOE allele frequencies were ε2: 5.3%, ε3: 88.2%, ε4: 6.5%. The ε4 allele frequency of 6.5% in the Greek population is, together with the frequency in the Chinese population, among the lowest in the world.

KW - Apolipoprotein E

KW - DNA polymorphism

KW - Greek population

KW - Population genetics

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JO - Clinical Genetics

JF - Clinical Genetics

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ER -

Apolipoprotein E polymorphism in the Greek population

Abstract

Keywords

ASJC Scopus subject areas

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