Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton, Anthony Payton, Eelke H. Van den Boogerd, Fiona Holland, Peter Diggle, Patrick M A Rabbitt, Michael A. Horan, Jane Worthington, William E R Ollier

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

Original languageEnglish (US)
Pages (from-to)74-76
Number of pages3
JournalNeuroscience Letters
Issue number1
StatePublished - May 10 2002
Externally publishedYes


  • Aged
  • Apolipoprotein E
  • Genetics
  • Intelligence

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults'. Together they form a unique fingerprint.

Cite this