Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton; Anthony Payton; Eelke H. Van den Boogerd; Fiona Holland; Peter Diggle; Patrick M A Rabbitt; Michael A. Horan; Jane Worthington; William E R Ollier

doi:10.1016/S0304-3940(02)00135-0

Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Neil Pendleton, Anthony Payton, Eelke H. Van den Boogerd, Fiona Holland, Peter Diggle, Patrick M A Rabbitt, Michael A. Horan, Jane Worthington, William E R Ollier

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

Original language	English (US)
Pages (from-to)	74-76
Number of pages	3
Journal	Neuroscience Letters
Volume	324
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(02)00135-0
State	Published - May 10 2002
Externally published	Yes

Keywords

Aged
Apolipoprotein E
Genetics
Intelligence

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(02)00135-0

Cite this

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title = "Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults",

abstract = "There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.",

keywords = "Aged, Apolipoprotein E, Genetics, Intelligence",

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AU - Pendleton, Neil

AU - Payton, Anthony

AU - Van den Boogerd, Eelke H.

AU - Holland, Fiona

AU - Diggle, Peter

AU - Rabbitt, Patrick M A

AU - Horan, Michael A.

AU - Worthington, Jane

AU - Ollier, William E R

PY - 2002/5/10

Y1 - 2002/5/10

N2 - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

AB - There is evidence of a genetic influence on the decline in cognitive performance of older adults, although the mechanisms responsible are unknown. A group of 767 subjects of the Manchester University Age and Cognitive Performance longitudinal study volunteer group, followed up from 1985 to the present, were genotyped for apolipoprotein E (APOE). The data from this were related to cross-sectional and longitudinal trends in the Heim intelligence test score (AH4-1) using previously reported random-effects models (Neuropsychologia 39 (2001) 532). There were no significant differences in mean scores for presence compared with absence of the APOE4 or APOE2 genotypes (P=0.48 and P=0.51, respectively). This research does not demonstrate a link between intelligence and APOE genotype in older adults.

KW - Aged

KW - Apolipoprotein E

KW - Genetics

KW - Intelligence

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Apolipoprotein E genotype does not predict decline in intelligence in healthy older adults

Abstract

Keywords

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