TY - JOUR
T1 - Apolipoprotein E gene polymorphisms and retinal vascular signs
T2 - The Atherosclerosis Risk In Communities (ARIC) Study
AU - Liew, Gerald
AU - Shankar, Anoop
AU - Jie, Jin Wang
AU - Klein, Ronald
AU - Bray, Molly S.
AU - Couper, David J.
AU - Sharrett, A. Richey
AU - Wong, Tien Y.
PY - 2007/6
Y1 - 2007/6
N2 - Objective: To examine the association between apolipoprotein E (APOE) gene polymorphisms and retinal microvascular signs. Methods: Population-based, cross-sectional study. Participants from the Atherosclerosis Risk in Communities Study (n=10 036; aged 49-73 years) had retinal photographs taken in 1 randomly selected eye. Photographs were graded for presence of retinal microvascular signs using a standardized protocol; a computer-assisted method was used to measure retinal vessel diameter. DNA from blood samples was analyzed for common APOE alleles. Results: After adjusting for age, sex, systolic blood pressure, total serum cholesterol, triglycerides, and other covariates, APOE ε4 was associated with nondiabetic retinopathy in white (multivariate-adjusted odds ratio, 1.3;95% confidence interval, 1.0-1.6) and black (multivariate-adjusted odds ratio, 1.4; 95% confidence interval, 1.0-2.1) individuals. Other retinal microvascular signs were not strongly associated with APOE polymorphisms. Neither retinal arteriolar nor venular diameter was associated with APOE polymorphisms in white or black individuals. Conclusions: Apolipoprotein E ε4 was weakly associated with retinopathy in persons without diabetes. Other signs were less consistently associated with APOE polymorphisms.
AB - Objective: To examine the association between apolipoprotein E (APOE) gene polymorphisms and retinal microvascular signs. Methods: Population-based, cross-sectional study. Participants from the Atherosclerosis Risk in Communities Study (n=10 036; aged 49-73 years) had retinal photographs taken in 1 randomly selected eye. Photographs were graded for presence of retinal microvascular signs using a standardized protocol; a computer-assisted method was used to measure retinal vessel diameter. DNA from blood samples was analyzed for common APOE alleles. Results: After adjusting for age, sex, systolic blood pressure, total serum cholesterol, triglycerides, and other covariates, APOE ε4 was associated with nondiabetic retinopathy in white (multivariate-adjusted odds ratio, 1.3;95% confidence interval, 1.0-1.6) and black (multivariate-adjusted odds ratio, 1.4; 95% confidence interval, 1.0-2.1) individuals. Other retinal microvascular signs were not strongly associated with APOE polymorphisms. Neither retinal arteriolar nor venular diameter was associated with APOE polymorphisms in white or black individuals. Conclusions: Apolipoprotein E ε4 was weakly associated with retinopathy in persons without diabetes. Other signs were less consistently associated with APOE polymorphisms.
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U2 - 10.1001/archopht.125.6.813
DO - 10.1001/archopht.125.6.813
M3 - Article
C2 - 17562993
AN - SCOPUS:34250305961
SN - 0003-9950
VL - 125
SP - 813
EP - 818
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 6
ER -