Apolipoprotein E and cognition in community-based samples of African Americans and Caucasians

Amy R. Borenstein, James A. Mortimer, Yougui Wu, Fern M. Jureidini-Webb, M. Daniele Fallin, Brent J. Small, Michael Mullan, Fiona C. Crawford

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


To compare relative frequencies of apolipoprotein E (APOE) alleles in African-American and Caucasian populations and test associations with cognition, we studied two community-based samples: one of 253 African Americans and another of 466 Caucasians age 60-84 years. Logistic regression, adjusting for age, sex, education, and history of hypertension and diabetes was used to associate APOE with five cognitive measures. The APOE-ε4 allele frequency was 29.5% in African Americans and 12.1% in Caucasians. In the African Americans, no association was found between the presence of the APOE-ε4 allele and any of the cognitive measures. Among Caucasians, APOE-ε4 carriers performed more poorly on three of the five tests. We also report a considerably higher frequency of the APOE-ε4 allele in our African-American sample compared to other US-based studies.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalEthnicity and Disease
Issue number1
StatePublished - 2006


  • Apolipoproteins E
  • Cognition
  • Gene frequency
  • Racial groups

ASJC Scopus subject areas

  • Epidemiology


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