Apolipoprotein e allele and hearing thresholds in older adults

David J. Mener; Joshua Betz; Kristine Yaffe; Tamara B. Harris; Elizabeth P. Helzner; Suzanne Satterfield; Denise K. Houston; Elsa S. Strotmeyer; Sheila R. Pratt; Eleanor M. Simonsick; Frank R. Lin

doi:10.1177/1533317514537549

Apolipoprotein e allele and hearing thresholds in older adults

David J. Mener, Joshua Betz, Kristine Yaffe, Tamara B. Harris, Elizabeth P. Helzner, Suzanne Satterfield, Denise K. Houston, Elsa S. Strotmeyer, Sheila R. Pratt, Eleanor M. Simonsick, Frank R. Lin

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Background: Whether apolipoprotein E (APOE) E4 allele status which is associated with an increased risk of cognitive decline is also associated with hearing impairment is unknown. Methods: We studied 1833 men and women enrolled in the Health, Aging and Body Composition study. Regression models adjusted for demographic and cardiovascular risk factors were used to assess the cross-sectional association of APOE-E4 status with individual pure tone hearing thresholds and the 4-frequency pure tone average (0.5-4 kHz) in the better hearing ear. Results: Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P =.013) and 8.0 kHz (β = -3.05 kHz, P =.006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P =.021). Conclusion: Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.

Original language	English (US)
Pages (from-to)	34-39
Number of pages	6
Journal	American Journal of Alzheimer's Disease and Other Dementias
Volume	31
Issue number	1
DOIs	https://doi.org/10.1177/1533317514537549
State	Published - Feb 1 2016

Keywords

aging
apolipoprotein E
cognition
dementia
hearing loss
hearing thresholds

ASJC Scopus subject areas

General Neuroscience
Clinical Psychology
Geriatrics and Gerontology
Psychiatry and Mental health

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title = "Apolipoprotein e allele and hearing thresholds in older adults",

abstract = "Background: Whether apolipoprotein E (APOE) E4 allele status which is associated with an increased risk of cognitive decline is also associated with hearing impairment is unknown. Methods: We studied 1833 men and women enrolled in the Health, Aging and Body Composition study. Regression models adjusted for demographic and cardiovascular risk factors were used to assess the cross-sectional association of APOE-E4 status with individual pure tone hearing thresholds and the 4-frequency pure tone average (0.5-4 kHz) in the better hearing ear. Results: Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P =.013) and 8.0 kHz (β = -3.05 kHz, P =.006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P =.021). Conclusion: Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.",

keywords = "aging, apolipoprotein E, cognition, dementia, hearing loss, hearing thresholds",

author = "Mener, {David J.} and Joshua Betz and Kristine Yaffe and Harris, {Tamara B.} and Helzner, {Elizabeth P.} and Suzanne Satterfield and Houston, {Denise K.} and Strotmeyer, {Elsa S.} and Pratt, {Sheila R.} and Simonsick, {Eleanor M.} and Lin, {Frank R.}",

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doi = "10.1177/1533317514537549",

language = "English (US)",

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T1 - Apolipoprotein e allele and hearing thresholds in older adults

AU - Mener, David J.

AU - Betz, Joshua

AU - Yaffe, Kristine

AU - Harris, Tamara B.

AU - Helzner, Elizabeth P.

AU - Satterfield, Suzanne

AU - Houston, Denise K.

AU - Strotmeyer, Elsa S.

AU - Pratt, Sheila R.

AU - Simonsick, Eleanor M.

AU - Lin, Frank R.

N1 - Publisher Copyright: © The Author(s) 2015.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Background: Whether apolipoprotein E (APOE) E4 allele status which is associated with an increased risk of cognitive decline is also associated with hearing impairment is unknown. Methods: We studied 1833 men and women enrolled in the Health, Aging and Body Composition study. Regression models adjusted for demographic and cardiovascular risk factors were used to assess the cross-sectional association of APOE-E4 status with individual pure tone hearing thresholds and the 4-frequency pure tone average (0.5-4 kHz) in the better hearing ear. Results: Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P =.013) and 8.0 kHz (β = -3.05 kHz, P =.006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P =.021). Conclusion: Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.

AB - Background: Whether apolipoprotein E (APOE) E4 allele status which is associated with an increased risk of cognitive decline is also associated with hearing impairment is unknown. Methods: We studied 1833 men and women enrolled in the Health, Aging and Body Composition study. Regression models adjusted for demographic and cardiovascular risk factors were used to assess the cross-sectional association of APOE-E4 status with individual pure tone hearing thresholds and the 4-frequency pure tone average (0.5-4 kHz) in the better hearing ear. Results: Compared to participants with no APOE-E4 alleles, participants with 1 allele had better thresholds at 4.0 kHz (β = -2.72 dB, P =.013) and 8.0 kHz (β = -3.05 kHz, P =.006), and participants with 2 alleles had better hearing thresholds at 1.0 kHz (β = -8.56 dB, P =.021). Conclusion: Our results suggest that APOE-E4 allele status may be marginally associated with better hearing thresholds in older adults.

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KW - cognition

KW - dementia

KW - hearing loss

KW - hearing thresholds

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Apolipoprotein e allele and hearing thresholds in older adults

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