Apolipoprotein E ε2 allele and risk of stroke in the older population

Luigi Ferrucci, Jack M. Guralnik, Marco Pahor, Tamara Harris, Maria Chiara Corti, Brad T. Hyman, Robert B. Wallace, Richard J. Havlik

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


Background and Purpose: There is evidence for a role of apolipoprotein E (apoE) in atherosclerosis. Coronary heart disease morbidity is higher in persons carrying an ε4 allele and lower in those carrying an ε2 allele, but the effect on cerebrovascular disease is controversial. We estimated the risk of stroke associated with different apoE genotypes in older persons. Methods: At the sixth annual follow-up of the Iowa cohort of the Established Populations for Epidemiologic Studies of the Elderly, 1664 persons aged ≤71 years and free of stroke were genotyped for apo E. Occurrence of ischemic strokes was prospectively assessed from subsequent hospital discharge records and death certificates. Results: One hundred fifty persons had an ischemic stroke over the subsequent 5 years (21.2 per 1000 person-years). The presence of ε3 and ε4 did not influence stroke risk. Among persons aged

Original languageEnglish (US)
Pages (from-to)2410-2416
Number of pages7
Issue number12
StatePublished - Dec 1997
Externally publishedYes


  • Aging
  • Apolipoproteins
  • Risk factors
  • Stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • General Neuroscience


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