APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI

Gregory Aldrich; James E. Evans; Roderick Davis; Lucia Jurin; Sarah Oberlin; Daniel Niedospial; Aurore Nkiliza; Michael Mullan; Kimbra Kenney; J. Kent Werner; Katie Edwards; Jessica Gill; Hannah M. Lindsey; Emily L. Dennis; William C. Walker; Elisabeth Wilde; Fiona Crawford; Laila Abdullah

doi:10.1038/s41598-024-80153-3

APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI

Gregory Aldrich, James E. Evans, Roderick Davis, Lucia Jurin, Sarah Oberlin, Daniel Niedospial, Aurore Nkiliza, Michael Mullan, Kimbra Kenney, J. Kent Werner, Katie Edwards, Jessica Gill, Hannah M. Lindsey, Emily L. Dennis, William C. Walker, Elisabeth Wilde, Fiona Crawford, Laila Abdullah

School of Nursing

Research output: Contribution to journal › Article › peer-review

Abstract

A reduction in the thickness and volume of the brain entorhinal cortex (EC), together with changes in blood arachidonic acid (AA) and docosahexaenoic acid (DHA), are associated with Alzheimer’s disease (AD) among apolipoprotein E ε4 carriers. Magnetic Resonance Imaging (n = 631) and plasma lipidomics (n = 181) were performed using the LIMBIC/CENC cohort to examine the influence of ε4 on AA- and DHA-lipids and EC thickness and volume in relation to mild traumatic brain injury (mTBI). Results showed that left EC thickness was higher among ε4 carriers with mTBI. Repeated mTBI (r-mTBI) was associated with reduced right EC thickness after controlling for ε4, age and sex. Age, plus mTBI chronicity were linked to increased EC White Matter Volume (WMV). After controlling for age and sex, the advancing age of ε4 carriers with blast mTBI was associated with reduced right EC Grey Matter Volume (GMV) and thickness. Among ε4 carriers, plasma tau and Aβ40 were associated with mTBI and blast mTBI, respectively. Chronic mTBI, ε4 and AA to DHA ratios in phosphatidylcholine, ethanolamides, and phosphatidylethanolamine were associated with decreased left EC GMV and WMV. Further research is needed to explore these as biomarkers for detecting AD pathology following mTBI.

Original language	English (US)
Article number	29150
Journal	Scientific reports
Volume	14
Issue number	1
DOIs	https://doi.org/10.1038/s41598-024-80153-3
State	Published - Dec 2024

Keywords

Apolipoprotein E
Arachidonic acid
Blast injury
Docosahexaenoic acid
Entorhinal cortex
Repetitive mild traumatic brain injury
Traumatic brain injury

ASJC Scopus subject areas

General

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10.1038/s41598-024-80153-3

Cite this

Aldrich, G., Evans, J. E., Davis, R., Jurin, L., Oberlin, S., Niedospial, D., Nkiliza, A., Mullan, M., Kenney, K., Werner, J. K., Edwards, K., Gill, J., Lindsey, H. M., Dennis, E. L., Walker, W. C., Wilde, E., Crawford, F., & Abdullah, L. (2024). APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI. Scientific reports, 14(1), Article 29150. https://doi.org/10.1038/s41598-024-80153-3

Aldrich, G, Evans, JE, Davis, R, Jurin, L, Oberlin, S, Niedospial, D, Nkiliza, A, Mullan, M, Kenney, K, Werner, JK, Edwards, K , Gill, J, Lindsey, HM, Dennis, EL, Walker, WC, Wilde, E, Crawford, F & Abdullah, L 2024, 'APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI', Scientific reports, vol. 14, no. 1, 29150. https://doi.org/10.1038/s41598-024-80153-3

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abstract = "A reduction in the thickness and volume of the brain entorhinal cortex (EC), together with changes in blood arachidonic acid (AA) and docosahexaenoic acid (DHA), are associated with Alzheimer{\textquoteright}s disease (AD) among apolipoprotein E ε4 carriers. Magnetic Resonance Imaging (n = 631) and plasma lipidomics (n = 181) were performed using the LIMBIC/CENC cohort to examine the influence of ε4 on AA- and DHA-lipids and EC thickness and volume in relation to mild traumatic brain injury (mTBI). Results showed that left EC thickness was higher among ε4 carriers with mTBI. Repeated mTBI (r-mTBI) was associated with reduced right EC thickness after controlling for ε4, age and sex. Age, plus mTBI chronicity were linked to increased EC White Matter Volume (WMV). After controlling for age and sex, the advancing age of ε4 carriers with blast mTBI was associated with reduced right EC Grey Matter Volume (GMV) and thickness. Among ε4 carriers, plasma tau and Aβ40 were associated with mTBI and blast mTBI, respectively. Chronic mTBI, ε4 and AA to DHA ratios in phosphatidylcholine, ethanolamides, and phosphatidylethanolamine were associated with decreased left EC GMV and WMV. Further research is needed to explore these as biomarkers for detecting AD pathology following mTBI.",

keywords = "Apolipoprotein E, Arachidonic acid, Blast injury, Docosahexaenoic acid, Entorhinal cortex, Repetitive mild traumatic brain injury, Traumatic brain injury",

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doi = "10.1038/s41598-024-80153-3",

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AU - Aldrich, Gregory

AU - Evans, James E.

AU - Davis, Roderick

AU - Jurin, Lucia

AU - Oberlin, Sarah

AU - Niedospial, Daniel

AU - Nkiliza, Aurore

AU - Mullan, Michael

AU - Kenney, Kimbra

AU - Werner, J. Kent

AU - Edwards, Katie

AU - Gill, Jessica

AU - Lindsey, Hannah M.

AU - Dennis, Emily L.

AU - Walker, William C.

AU - Wilde, Elisabeth

AU - Crawford, Fiona

AU - Abdullah, Laila

N1 - Publisher Copyright: © The Author(s) 2024.

PY - 2024/12

Y1 - 2024/12

N2 - A reduction in the thickness and volume of the brain entorhinal cortex (EC), together with changes in blood arachidonic acid (AA) and docosahexaenoic acid (DHA), are associated with Alzheimer’s disease (AD) among apolipoprotein E ε4 carriers. Magnetic Resonance Imaging (n = 631) and plasma lipidomics (n = 181) were performed using the LIMBIC/CENC cohort to examine the influence of ε4 on AA- and DHA-lipids and EC thickness and volume in relation to mild traumatic brain injury (mTBI). Results showed that left EC thickness was higher among ε4 carriers with mTBI. Repeated mTBI (r-mTBI) was associated with reduced right EC thickness after controlling for ε4, age and sex. Age, plus mTBI chronicity were linked to increased EC White Matter Volume (WMV). After controlling for age and sex, the advancing age of ε4 carriers with blast mTBI was associated with reduced right EC Grey Matter Volume (GMV) and thickness. Among ε4 carriers, plasma tau and Aβ40 were associated with mTBI and blast mTBI, respectively. Chronic mTBI, ε4 and AA to DHA ratios in phosphatidylcholine, ethanolamides, and phosphatidylethanolamine were associated with decreased left EC GMV and WMV. Further research is needed to explore these as biomarkers for detecting AD pathology following mTBI.

AB - A reduction in the thickness and volume of the brain entorhinal cortex (EC), together with changes in blood arachidonic acid (AA) and docosahexaenoic acid (DHA), are associated with Alzheimer’s disease (AD) among apolipoprotein E ε4 carriers. Magnetic Resonance Imaging (n = 631) and plasma lipidomics (n = 181) were performed using the LIMBIC/CENC cohort to examine the influence of ε4 on AA- and DHA-lipids and EC thickness and volume in relation to mild traumatic brain injury (mTBI). Results showed that left EC thickness was higher among ε4 carriers with mTBI. Repeated mTBI (r-mTBI) was associated with reduced right EC thickness after controlling for ε4, age and sex. Age, plus mTBI chronicity were linked to increased EC White Matter Volume (WMV). After controlling for age and sex, the advancing age of ε4 carriers with blast mTBI was associated with reduced right EC Grey Matter Volume (GMV) and thickness. Among ε4 carriers, plasma tau and Aβ40 were associated with mTBI and blast mTBI, respectively. Chronic mTBI, ε4 and AA to DHA ratios in phosphatidylcholine, ethanolamides, and phosphatidylethanolamine were associated with decreased left EC GMV and WMV. Further research is needed to explore these as biomarkers for detecting AD pathology following mTBI.

KW - Apolipoprotein E

KW - Arachidonic acid

KW - Blast injury

KW - Docosahexaenoic acid

KW - Entorhinal cortex

KW - Repetitive mild traumatic brain injury

KW - Traumatic brain injury

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C2 - 39587176

AN - SCOPUS:85210079019

SN - 2045-2322

VL - 14

JO - Scientific reports

JF - Scientific reports

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ER -

APOE4 and age affect the brain entorhinal cortex structure and blood arachidonic acid and docosahexaenoic acid levels after mild TBI

Abstract

Keywords

ASJC Scopus subject areas

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