TY - JOUR
T1 - APOE genotype and nonrespiratory sleep parameters in cognitively intact older adults
AU - Spira, Adam P.
AU - An, Yang
AU - Peng, Yu
AU - Wu, Mark N.
AU - Simonsick, Eleanor M.
AU - Ferrucci, Luigi
AU - Resnick, Susan M.
N1 - Funding Information:
This study was supported in part by the Intramural Research Program (IRP), National Institute on Aging (NIA), National Institutes of Health (NIH), and by Research and Development Contract HHSN-260-2004-00012C. Dr. Spira was supported in part by R01AG050507 and other grants from the NIA and has received funding from the William and Ella Owens Medical Research Foundation. Investigators from the NIH NIA IRP were involved in all aspects of this manuscript, including the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Publisher Copyright:
© 2017 Oxford University Press. All Rights Reserved.
PY - 2017/8
Y1 - 2017/8
N2 - Study Objectives: The apolipoprotein E (APOE) ϵ4 allele increases Alzheimer's disease (AD) risk and has been linked to a greater risk of sleep-disordered breathing. We investigated the association of APOE genotype with nonrespiratory sleep parameters. Methods: We studied 1264 cognitively normal participants in the Baltimore Longitudinal Study of Aging (mean = 57.5 ± 16.1 years, range 19.9-92.0, 48.2% women, 19.8% African American) with APOE genotyping and self-reported sleep duration (≥9, 7 or 8, ≤6 hours), difficulty falling/staying asleep, and napping. We compared ϵ4 carriers with all noncarriers and compared persons at reduced (ϵ2/ϵ2 or ϵ2/ϵ3) or elevated AD risk (≥1 ϵ4 allele) with those neutral for AD risk (ϵ3/ϵ3). Results: In fully adjusted models, those with ≥1 ϵ4 allele had a greater odds of being in a shorter sleep duration category compared to all noncarriers (odds ratio [OR] = 1.41, 95% confidence interval [CI] 1.06, 1.88) and ϵ3/ϵ3 carriers (OR = 1.43, 95% CI 1.06, 1.92). Compared to ϵ3/ϵ3 carriers, ϵ2/ϵ2 or ϵ2/ϵ3 carriers had a lower odds of reporting napping (OR = 0.64, 95% CI 0.43, 0.96). Among participants aged ≥50 years, sleep duration findings remained and ϵ4 carriers had a greater odds of trouble falling/staying asleep than noncarriers (OR = 1.49, 95% CI 1.02, 2.17). We found some evidence for stronger associations of ϵ4 with sleep duration among African Americans. Conclusions: Self-reported sleep duration, napping, and trouble falling/staying asleep differ by APOE genotype. Studies are needed to examine whether APOE promotes AD by degrading sleep and to clarify the role of race in these associations.
AB - Study Objectives: The apolipoprotein E (APOE) ϵ4 allele increases Alzheimer's disease (AD) risk and has been linked to a greater risk of sleep-disordered breathing. We investigated the association of APOE genotype with nonrespiratory sleep parameters. Methods: We studied 1264 cognitively normal participants in the Baltimore Longitudinal Study of Aging (mean = 57.5 ± 16.1 years, range 19.9-92.0, 48.2% women, 19.8% African American) with APOE genotyping and self-reported sleep duration (≥9, 7 or 8, ≤6 hours), difficulty falling/staying asleep, and napping. We compared ϵ4 carriers with all noncarriers and compared persons at reduced (ϵ2/ϵ2 or ϵ2/ϵ3) or elevated AD risk (≥1 ϵ4 allele) with those neutral for AD risk (ϵ3/ϵ3). Results: In fully adjusted models, those with ≥1 ϵ4 allele had a greater odds of being in a shorter sleep duration category compared to all noncarriers (odds ratio [OR] = 1.41, 95% confidence interval [CI] 1.06, 1.88) and ϵ3/ϵ3 carriers (OR = 1.43, 95% CI 1.06, 1.92). Compared to ϵ3/ϵ3 carriers, ϵ2/ϵ2 or ϵ2/ϵ3 carriers had a lower odds of reporting napping (OR = 0.64, 95% CI 0.43, 0.96). Among participants aged ≥50 years, sleep duration findings remained and ϵ4 carriers had a greater odds of trouble falling/staying asleep than noncarriers (OR = 1.49, 95% CI 1.02, 2.17). We found some evidence for stronger associations of ϵ4 with sleep duration among African Americans. Conclusions: Self-reported sleep duration, napping, and trouble falling/staying asleep differ by APOE genotype. Studies are needed to examine whether APOE promotes AD by degrading sleep and to clarify the role of race in these associations.
KW - APOE
KW - Genotype
KW - Napping
KW - Older adults
KW - Sleep
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U2 - 10.1093/sleep/zsx076
DO - 10.1093/sleep/zsx076
M3 - Article
C2 - 28482100
AN - SCOPUS:85033373984
SN - 0161-8105
VL - 40
SP - 1
EP - 8
JO - Sleep
JF - Sleep
IS - 8
ER -