Apo-Opsin and Its Dark Constitutive Activity across Retinal Cone Subtypes

Donggen Luo, Daniel Silverman, Rikard Frederiksen, Rajan Adhikari, Li Hui Cao, John E. Oatis, Masahiro Kono, M. Carter Cornwall, King Wai Yau

Research output: Contribution to journalArticlepeer-review


Cone, but not rod, pigments can dissociate in darkness into apo-opsin and chromophore without isomerization, but this cone pigment property has been generally overlooked. Luo et al. report experiments showing that the dark apo-opsin content especially in L cones is substantial, producing dark noise that may constrain cone photodetection threshold.

Original languageEnglish (US)
Pages (from-to)4921-4931.e5
JournalCurrent Biology
Issue number24
StatePublished - Dec 21 2020


  • cone photodetection threshold
  • cone phototransduction
  • constitutive apo-opsin activity
  • dark noise
  • truncated-cone recording

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)


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