TY - JOUR
T1 - Aortic pulse pressure is associated with carotid IMT in chronic kidney disease
T2 - Report from chronic renal insufficiency cohort
AU - Deloach, Stephanie S.
AU - Appel, Lawrence J.
AU - Chen, Jing
AU - Joffe, Marshall M.
AU - Gadegbeku, Crystal A.
AU - Mohler, Emile R.
AU - Parsa, Afshin
AU - Perumal, Kalyani
AU - Rafey, Mohammed A.
AU - Steigerwalt, Susan P.
AU - Teal, Valerie
AU - Townsend, Raymond R.
AU - Rosas, Sylvia E.
N1 - Funding Information:
Acknowledgments: S.S.d. was supported by a research supplement to National Institutes of Health (NIH) grant dK-067390. S.E.R. was supported by NIH grant dK-064343 from the National Institute of diabetes and digestive and Kidney diseases, andVA Merit Award IIR05-247 from theVeterans Health Administration. R.R.T. was supported by NIH grants dK-067390 and dK-060984. The project described was also supported by grant no. UL1RR024134 from the National center for Research Resources.We thank all investigators of the chronic Renal Insufficiency cohort Study for their contributions.
PY - 2009/12
Y1 - 2009/12
N2 - Background Patients with chronic kidney disease (CKD) have a disproportionate risk of cardiovascular disease. This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study.MethodsThree hundred and sixty-seven subjects with CKD enrolled in the CRIC study at the University of Pennsylvania site (mean age 59.9 years, blood pressure 129/74 mm Hg, estimated glomerular filtration rate 48 ml/min/1.73 m 2, IMT 0.8 mm) had both carotid IMT and PWA measurements. Carotid ultrasound was also used to determine the presence of plaque. PWA was used to determine augmentation index (AI), amplification ratio (AMPR), aortic pulse pressure (C-PP), and central aortic systolic pressure (C-SP).ResultsIMT was significantly associated with all PWA-derived measures. However, on multivariable linear regression analysis, only AMPR (regression coefficient 0.072, P = 0.006), C-PP (regression coefficient 0.0025, P 0.001), and C-SP (regression coefficient 0.0017, P 0.001) remained significantly associated with IMT. The prevalence of carotid plaque in the cohort was 59%. Of the PWA-derived measures, only C-PP was significantly associated with the presence of carotid plaque (P 0.001).ConclusionsPWA-derived measures are associated with carotid IMT and plaque in the CKD. Of these measures, C-PP was most associated with carotid IMT and plaque.
AB - Background Patients with chronic kidney disease (CKD) have a disproportionate risk of cardiovascular disease. This study was designed to assess the association between two noninvasive measures of cardiovascular risk, pulse wave analysis (PWA), and carotid intima-media thickness (IMT), in a cohort of CKD patients enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study.MethodsThree hundred and sixty-seven subjects with CKD enrolled in the CRIC study at the University of Pennsylvania site (mean age 59.9 years, blood pressure 129/74 mm Hg, estimated glomerular filtration rate 48 ml/min/1.73 m 2, IMT 0.8 mm) had both carotid IMT and PWA measurements. Carotid ultrasound was also used to determine the presence of plaque. PWA was used to determine augmentation index (AI), amplification ratio (AMPR), aortic pulse pressure (C-PP), and central aortic systolic pressure (C-SP).ResultsIMT was significantly associated with all PWA-derived measures. However, on multivariable linear regression analysis, only AMPR (regression coefficient 0.072, P = 0.006), C-PP (regression coefficient 0.0025, P 0.001), and C-SP (regression coefficient 0.0017, P 0.001) remained significantly associated with IMT. The prevalence of carotid plaque in the cohort was 59%. Of the PWA-derived measures, only C-PP was significantly associated with the presence of carotid plaque (P 0.001).ConclusionsPWA-derived measures are associated with carotid IMT and plaque in the CKD. Of these measures, C-PP was most associated with carotid IMT and plaque.
UR - http://www.scopus.com/inward/record.url?scp=70450223709&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70450223709&partnerID=8YFLogxK
U2 - 10.1038/ajh.2009.156
DO - 10.1038/ajh.2009.156
M3 - Article
C2 - 19779470
AN - SCOPUS:70450223709
SN - 0895-7061
VL - 22
SP - 1235
EP - 1241
JO - American Journal of Hypertension
JF - American Journal of Hypertension
IS - 12
ER -