Anxiety in Wiedemann–Steiner syndrome

Rowena Ng; Hans Tomas Bjornsson; Jill A. Fahrner; Jacqueline Harris

doi:10.1002/ajmg.a.63040

Anxiety in Wiedemann–Steiner syndrome

Rowena Ng, Hans Tomas Bjornsson, Jill A. Fahrner, Jacqueline Harris

Research output: Contribution to journal › Article › peer-review

Abstract

This study examined anxiety in Wiedemann–Steiner syndrome (WSS). Eighteen caregivers and participants with WSS completed the parent- and self-report versions of the Screen for Child Anxiety Related Disorder or the adapted version of the Screen for Adult Anxiety Related Disorder. Approximately 33.33% of parents and 65% of participants with WSS rated in the clinical range for overall anxiety. Across anxiety subtypes, parents primarily indicated concerns with Separation Anxiety (72%), which was also endorsed by the majority of participants with WSS (82%). The emergent trend showed Total Anxiety increased with age based on parent-informant ratings. The behavioral phenotype of WSS includes elevated anxiety. Clinical management should include incorporating early behavioral interventions to bolster emotion regulation given the observed risk of anxiety with age.

Original language	English (US)
Pages (from-to)	437-444
Number of pages	8
Journal	American Journal of Medical Genetics, Part A
Volume	191
Issue number	2
DOIs	https://doi.org/10.1002/ajmg.a.63040
State	Published - Feb 2023

Keywords

KMT2A
anxiety
developmental psychopathology
genetics/genetic disorders
mental health

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1002/ajmg.a.63040

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title = "Anxiety in Wiedemann–Steiner syndrome",

abstract = "This study examined anxiety in Wiedemann–Steiner syndrome (WSS). Eighteen caregivers and participants with WSS completed the parent- and self-report versions of the Screen for Child Anxiety Related Disorder or the adapted version of the Screen for Adult Anxiety Related Disorder. Approximately 33.33% of parents and 65% of participants with WSS rated in the clinical range for overall anxiety. Across anxiety subtypes, parents primarily indicated concerns with Separation Anxiety (72%), which was also endorsed by the majority of participants with WSS (82%). The emergent trend showed Total Anxiety increased with age based on parent-informant ratings. The behavioral phenotype of WSS includes elevated anxiety. Clinical management should include incorporating early behavioral interventions to bolster emotion regulation given the observed risk of anxiety with age.",

keywords = "KMT2A, anxiety, developmental psychopathology, genetics/genetic disorders, mental health",

author = "Rowena Ng and Bjornsson, {Hans Tomas} and Fahrner, {Jill A.} and Jacqueline Harris",

note = "Funding Information: R.N. and H.T.B. are supported by grants from the WSS Foundation, J.A.F. has support from The Hartwell Foundation (Individual Biomedical Research Award) and the NIH (K08HD086250), and J.H. has support from the National Institute of Child Health and Development (K23HD101646). This study was also supported by Kennedy Krieger IDDRC NIH (P50HD103538). Funding Information: We would like to thank the patients and their families who participated in this study, as well as acknowledging the support of the Wiedemann–Steiner Syndrome Foundation. Publisher Copyright: {\textcopyright} 2022 Wiley Periodicals LLC.",

year = "2023",

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doi = "10.1002/ajmg.a.63040",

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AU - Harris, Jacqueline

N1 - Funding Information: R.N. and H.T.B. are supported by grants from the WSS Foundation, J.A.F. has support from The Hartwell Foundation (Individual Biomedical Research Award) and the NIH (K08HD086250), and J.H. has support from the National Institute of Child Health and Development (K23HD101646). This study was also supported by Kennedy Krieger IDDRC NIH (P50HD103538). Funding Information: We would like to thank the patients and their families who participated in this study, as well as acknowledging the support of the Wiedemann–Steiner Syndrome Foundation. Publisher Copyright: © 2022 Wiley Periodicals LLC.

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Anxiety in Wiedemann–Steiner syndrome

Abstract

Keywords

ASJC Scopus subject areas

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