Antivascular photo-mediated ultrasound therapy

In this work, a new therapeutic technique targeting blood vessels based on photo-mediated ultrasound therapy (PUT) was evaluated. By synergistically applying ultrasound waves on the target tissue during laser ablation, the cavitation effect can be greatly enhanced. This technique was applied to remove small blood vessels in a chicken embryo model and demonstrated promising outcomes. The treated blood vessels were either completely removed or significantly shrunk in size. In the control experiment where samples were treated with either ultrasound or laser alone, no changes in blood vessels were observed. With the advantages including high selectivity, high efficiency and label free, the developed PUT technique could be a new tool for treating a variety of diseases involving abnormal vasculature.