Antisecretory mechanisms of Peptide YY in rat distal colon

Edward E. Whang, Oscar J. Hines, Joseph R. Reeve, Daniel Grandt, James A. Moser, Anton J. Bilchik, Michael J. Zinner, David W. McFadden, Stanley W. Ashley

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Peptide YY (PYY) is a potent regulator of intestinal secretion. These studies investigated the role of Y1 and Y2 receptor subtypes in mediating the antisecretory effects of PYY on mucosa-submucosa preparations of rat distal colon. Addition of vasoactive intestinal peptide (VIP) to these tissues resulted in a 140 ± 18% increase in basal short-circuit current (I(sc)) and the induction of Cl secretion. VIP-stimulated increases in I(sc) were abolished by the addition of each of PYY, (Pro34)-PYY, a Y1 receptor- selective agonist, and PYY-(3-36), an endogenous Y2 receptor-selective ligand. However, when tissue neural transmission was blocked with tetrodotoxin, neither PYY nor its receptor subtype-selective analogs were able to inhibit VIP-stimulated increases in I(sc). These results suggest that in the rat distal colon, the antisecretory actions of PYY are mediated through a combination of Y1 and Y2 receptor subtypes or through a novel receptor subtype that is unable to discriminate between (Pro34)-PYY and PYY-(3-36).

Original languageEnglish (US)
Pages (from-to)1121-1127
Number of pages7
JournalDigestive diseases and sciences
Issue number6
StatePublished - 1997
Externally publishedYes


  • Colon
  • Intestinal secretion
  • Neuropeptide Y
  • Peptide YY

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology


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