Antiretroviral treatment, management challenges and outcomes in perinatally HIV-infected adolescents

Allison L. Agwu, Lee Fairlie

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


Three decades into the HIV/AIDS epidemic there is a growing cohort of perinatally HIV-infected adolescents globally. Their survival into adolescence and beyond represent one of the major successes in the battle against the disease that has claimed the lives of millions of children. This population is diverse and there are unique issues related to antiretroviral treatment and management. Drawing from the literature and experience, this paper discusses several broad areas related to antiretroviral management, including: 1) diverse presentation of HIV, (2) use of combination antiretroviral therapy including in the setting of co-morbidities and rapid growth and development, (3) challenges of cART, including nonadherence, resistance, and management of the highly treatment-experienced adolescent patient, (4) additional unique concerns and management issues related to PHIV-infected adolescents, including the consequences of longterm inflammation, risk of transmission, and transitions to adult care. In each section, the experience in both resource-rich and limited settings are discussed with the aim of highlighting the differences and importantly the similarities, to share lessons learnt and provide insight into the multi-faceted approaches that may be needed to address the challenges faced by this unique and resilient population.

Original languageEnglish (US)
Article number18579
JournalJournal of the International AIDS Society
StatePublished - Jun 18 2013


  • Adolescents
  • Combination antiretroviral therapy
  • Management
  • Outcomes 10.7448/ias.16.1.18579
  • Perinatally HIV-infected
  • Resistance

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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