Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase

Sangwon F. Kim; Alex S. Huang; Adele M. Snowman; Cory Teuscher; Solomon H. Snyder

doi:10.1073/pnas.0611417104

Antipsychotic drug-induced weight gain mediated by histamine H₁ receptor-linked activation of hypothalamic AMP-kinase

Sangwon F. Kim, Alex S. Huang, Adele M. Snowman, Cory Teuscher, Solomon H. Snyder

School of Medicine

Research output: Contribution to journal › Article › peer-review

296 Scopus citations

Abstract

The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We report that orexigenic AAPDs potently and selectively activate hypothalamic AMP-kinase, an action abolished in mice with deletion of histamine H1 receptors. These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake.

Original language	English (US)
Pages (from-to)	3456-3459
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	104
Issue number	9
DOIs	https://doi.org/10.1073/pnas.0611417104
State	Published - Feb 27 2007

Keywords

Atypical antipsychotic drugs
Hypothalamus
Obesity

ASJC Scopus subject areas

General

Access to Document

10.1073/pnas.0611417104

Cite this

Antipsychotic drug-induced weight gain mediated by histamine H₁ receptor-linked activation of hypothalamic AMP-kinase. / Kim, Sangwon F.; Huang, Alex S.; Snowman, Adele M. et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, No. 9, 27.02.2007, p. 3456-3459.

Research output: Contribution to journal › Article › peer-review

@article{6fde3906c90142278d50727849179d4e,

title = "Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase",

abstract = "The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We report that orexigenic AAPDs potently and selectively activate hypothalamic AMP-kinase, an action abolished in mice with deletion of histamine H1 receptors. These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake.",

keywords = "Atypical antipsychotic drugs, Hypothalamus, Obesity",

author = "Kim, {Sangwon F.} and Huang, {Alex S.} and Snowman, {Adele M.} and Cory Teuscher and Snyder, {Solomon H.}",

year = "2007",

month = feb,

day = "27",

doi = "10.1073/pnas.0611417104",

language = "English (US)",

volume = "104",

pages = "3456--3459",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "9",

}

TY - JOUR

T1 - Antipsychotic drug-induced weight gain mediated by histamine H1 receptor-linked activation of hypothalamic AMP-kinase

AU - Kim, Sangwon F.

AU - Huang, Alex S.

AU - Snowman, Adele M.

AU - Teuscher, Cory

AU - Snyder, Solomon H.

PY - 2007/2/27

Y1 - 2007/2/27

N2 - The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We report that orexigenic AAPDs potently and selectively activate hypothalamic AMP-kinase, an action abolished in mice with deletion of histamine H1 receptors. These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake.

AB - The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We report that orexigenic AAPDs potently and selectively activate hypothalamic AMP-kinase, an action abolished in mice with deletion of histamine H1 receptors. These findings may afford a means of developing more effective therapeutic agents and provide insight into the hypothalamic regulation of food intake.

KW - Atypical antipsychotic drugs

KW - Hypothalamus

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=33847635179&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33847635179&partnerID=8YFLogxK

U2 - 10.1073/pnas.0611417104

DO - 10.1073/pnas.0611417104

M3 - Article

C2 - 17360666

AN - SCOPUS:33847635179

SN - 0027-8424

VL - 104

SP - 3456

EP - 3459

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

IS - 9

ER -