@article{00a6238c17844542bda08b1fc74c1b8e,
title = "Antiprotozoal activity profiling of approved drugs: A starting point toward drug repositioning",
abstract = "Neglected tropical diseases cause significant morbidity and mortality and are a source of poverty in endemic countries. Only a few drugs are available to treat diseases such as leish-maniasis, Chagas' disease, human African trypanosomiasis and malaria. Since drug development is lengthy and expensive, a drug repurposing strategy offers an attractive fast-track approach to speed up the process. A set of 100 registered drugs with drug repositioning potential for neglected diseases was assembled and tested in vitro against four protozoan parasites associated with the aforementioned diseases. Several drugs and drug classes showed in vitro activity in those screening assays. The results are critically reviewed and discussed in the perspective of a follow-up drug repositioning strategy where R&D has to be addressed with limited resources.",
author = "Marcel Kaiser and Pascal M{\"a}ser and Tadoori, {Leela Pavan} and Ioset, {Jean Robert} and Reto Brun and Sullivan, {David J.}",
note = "Funding Information: We acknowledge NIH-AIDS Research & Reference Reagent Program for the donation of the antiretroviral compounds. We thank M. Cal, S. Sax and S. Keller for assistance with parasite assays. The authors also wish to thank Drs Susan Wells and Christine Power (DNDi) for the critical reading as well as editing of the manuscript. This study was primarily funded by the Drugs for Neglected Diseases initiative. For the work described in this article, the Drugs for Neglected Diseases initiative received financial support from the following donors: Department for International Development (UK), Reconstruction Credit Institution–Federal Ministry of Education and Research (KfW-BMBF; Germany), Bill & Melinda Gates Foundation (United States), and M{\'e}decins Sans Fronti{\`e}res. The donors had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the article apart from those disclosed. Publisher Copyright: {\textcopyright} 2015 Kaiser et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2015",
month = aug,
day = "13",
doi = "10.1371/journal.pone.0135556",
language = "English (US)",
volume = "10",
journal = "PloS one",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",
}