Antiplatelet therapy: Clopidogrel-PPI interaction, an ongoing controversy

Paul A. Gurbel, Udaya S. Tantry

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Although a diminished pharmacodynamic effect of clopidogrel has been demonstrated in patients treated with proton-pump inhibitors (PPis), whether itsclinical efficacy is reduced remains highly controversial. The Fda and European Medicines agency recommend that PPis and clopidogrel should not routinely be coadministered, and the 2010 expert consensus guidelines support this recommendation.

Original languageEnglish (US)
Pages (from-to)7-8
Number of pages2
JournalNature Reviews Cardiology
Issue number1
StatePublished - Jan 2011

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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