Antioxidants and cardiovascular disease

Research output: Chapter in Book/Report/Conference proceedingChapter


Antioxidant vitamin supplements are regularly consumed by over one-third of all adults in the United States. While the health benefits of vitamin supplements are unproven, many lay persons and health professionals believe that pill supplementation with antioxidants is an effective strategy for the prevention and treatment of acute and chronic illnesses, including cardiovascular diseases (CVDs). Contrary to the commonly held beliefs, recent large-scale randomized clinical trials have repeatedly documented no benefit from antioxidant vitamin supplements. This chapter reviews evidence for biological plausibility; the major observational studies which linked antioxidant intake to reduced risk of cardiovascular and other chronic diseases. It reviews the large number of trials which, collectively, fail to show benefit of antioxidant vitamin supplement use in preventing CVD and mortality.

Original languageEnglish (US)
Title of host publicationCoronary Heart Disease Epidemiology
Subtitle of host publicationFrom Aetiology to Public Health
PublisherOxford University Press
ISBN (Electronic)9780191724114
ISBN (Print)9780198525738
StatePublished - Sep 1 2009


  • Antioxidant vitamin supplements
  • Biological plausibility
  • Cardiovascular disease
  • Coronary heart disease
  • Multivitamins

ASJC Scopus subject areas

  • General Psychology


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