@article{fc8797b319e04fefafdb81e91d4cccbc,
title = "Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment",
abstract = "HIV-associated cognitive neurological disorders (HAND) prevail in the antiretroviral therapy era. Proteomics analysis of CSF revealed expression of Cu/Zn superoxide dismutase (Cu/Zn SOD) in Hispanic women with cognitive impairment (CI). We tested the hypothesis that there is reduced capacity of antioxidant enzymes in CI by measures of expression and activity of Cu/Zn SOD, catalase, and Se-glutathione peroxidase in HAND. Our results showed that the function of these antioxidants was decreased in the CSF and monocytes of women with CI. These findings have important implications regarding their possible contribution to oxidative stress and in the diagnosis and therapy for HAND.",
keywords = "Antioxidant enzymes, Cu/Zn SOD, HAART, HIV-associated cognitive impairment, Women",
author = "Ixane Vel{\'a}zquez and Marin{\'e}s Plaud and Valerie Wojna and Richard Skolasky and Laspiur, {Juliana P{\'e}rez} and Mel{\'e}ndez, {Loyda M.}",
note = "Funding Information: This work was supported by grants NIH-SNRP 1 U54NS430, NIH-MBRS-SCORE-SO6GMO822 and NIH-RCMI-CRC P20RR11126. We thank the patients of the SNRP-NeuroAIDS Hispanic Women Cohort. Ms. Tania Ginebra and Dr. Tania de la Torre provided patient outreach. Ms. Elizabeth Maldonado organized patient demographics. We thank Dr. Rosa Hechavarr{\'i}a and Dr. Raul Mayo for neuropsychological testing. We thank Dr. Carmen Zorrilla and Dr. Hermes Garc{\'i}a, directors of the Centro de Estudios Materno Infantil (CEMI) and Centro Latinoamericano de Enfermedades de Transmisi{\'o}n Sexual (CLETS) respectively, who referred patients to the study. We thank Dr. Edmundo Kraiselburd, director of the SNRP-NeuroAIDS Program for his support in this study. We thank Dr. Howard Gendelman and Dr. Dale Benos for careful review of this manuscript.",
year = "2009",
month = jan,
day = "3",
doi = "10.1016/j.jneuroim.2008.10.013",
language = "English (US)",
volume = "206",
pages = "106--111",
journal = "Journal of Neuroimmunology",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",
}