Antioxidant effects of 1,5-anhydro-d-fructose, a new natural sugar, in vitro

Kazuyo Yamaji, Krishna Pada Sarker, Ikuro Maruyama, Susumu Hizukuri

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the formation of hydrogen peroxide and superoxide anion, typical reactive oxygen species (ROS), induced by phorbol myristate acetate (PMA) in a dose-dependent manner in THP-1 cells. We also observed the dose-dependent antioxidant effects of 1,5-AF on copper-mediated LDL oxidation. These findings suggest that 1,5-AF might play a role in reducing the risk of atherosclerosis and may help prevent coronary heart disease.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalPlanta Medica
Issue number1
StatePublished - Feb 11 2002


  • 1,5-Anhydro-D-fructose
  • Antioxidant
  • Low-density lipoprotein peroxidation
  • Reactive oxygen species

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry


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