Antinuclear antibodies in sera of patients with recurrent pregnancy wastage

Ling Xu, Victoria Chang, Ana Murphy, John A. Rock, Marian D. Damewood, William Schlaff, Howard A. Zacur

Research output: Contribution to journalArticlepeer-review

46 Scopus citations


Four groups of women were studied to determine whether low-level antinuclear antibody titers are associated with a higher risk for pregnancy loss. Group A consisted of 30 patients with a history of unexplained fetal losses. Group B consisted of 30 women with "explained" fetal losses (e.g., uterine septum or luteal phase defect). Ages and number of losses were comparable between the women in groups A and B. Group C consisted of 61 healthy pregnant women. Group D involved 61 healthy nonpregnant women of reproductive age. In groups A and B, 40% and 53.3% of the respective patients had antinuclear antibody titers ≥1 : 40. In groups C and D the frequencies of positive antinuclear antibody titers were 8.2% and 5.6%, respectively. This study demonstrates a high prevalence of low-titer antinuclear antibody-positive serum in patients with explained and unexplained pregnancy losses.

Original languageEnglish (US)
Pages (from-to)1493-1497
Number of pages5
JournalAmerican journal of obstetrics and gynecology
Issue number5 PART 1
StatePublished - Nov 1990


  • Repeated pregnancy wastage or losses
  • antinuclear antibody
  • habitual abortion

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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