Antimicrobial activity of antibiotic-soaked, Resist™-coated Bioflex®

W. J.G. Hellstrom, J. S. Hyun, L. Hmnan, J. A. Sanabria, T. J. Bivalacqua, S. Leungwattanakij

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


This study investigates whether a hydrophilic coating (Resist™), designed to inhibit bacterial adherence, applied to inflatable penile prostheses can prolong the effect of intraoperative antibiotics. The activity of antibiotic-soaked Bioflex® (penile prosthetic substrate material) discs with and without Resist™ was examined by measuring the zone of inhibition following in vivo exposure in four groups of rabbits: 1, 2, 3 and 5 days' duration of disc implantation. Coated and uncoated discs were soaked in an aqueous solution of gentamicin and bacitracin. The implanted antibiotic-soaked discs were extracted, and the zone of inhibition against four microorganisms in vitro demonstrated that the Resist™ coating was especially effective against Staphylococcus epidermidis, and statistically significant improvements were observed for the coated over the uncoated substrate up to 3 days following implantation. This effect, and the anti-adherence properties of Resist™, may prevent adhesion and colonization of some microorganisms to penile implants and reduce chances for infection.

Original languageEnglish (US)
Pages (from-to)18-21
Number of pages4
JournalInternational Journal of Impotence Research
Issue number1
StatePublished - 2003
Externally publishedYes


  • Antibiotics
  • Bioflex
  • Infection
  • Penile prosthesis

ASJC Scopus subject areas

  • Urology


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