Antigenic evolution of dengue viruses over 20 years

Leah C. Katzelnick; Ana Coello Escoto; Angkana T. Huang; Bernardo Garcia-Carreras; Nayeem Chowdhury; Irina Maljkovic Berry; Chris Chavez; Philippe Buchy; Veasna Duong; Philippe Dussart; Gregory Gromowski; Louis Macareo; Butsaya Thaisomboonsuk; Stefan Fernandez; Derek J. Smith; Richard Jarman; Stephen S. Whitehead; Henrik Salje; Derek A.T. Cummings

doi:10.1126/science.abk0058

Antigenic evolution of dengue viruses over 20 years

Leah C. Katzelnick
, Ana Coello Escoto
, Angkana T. Huang
, Bernardo Garcia-Carreras
, Nayeem Chowdhury
, Irina Maljkovic Berry
, Chris Chavez
, Philippe Buchy
, Veasna Duong
, Philippe Dussart
, Gregory Gromowski
, Louis Macareo
, Butsaya Thaisomboonsuk
, Stefan Fernandez
, Derek J. Smith
, Richard Jarman
, Stephen S. Whitehead
, Henrik Salje
, Derek A.T. Cummings

Research output: Contribution to journal › Article › peer-review

Abstract

Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcg receptor–bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944 sequenced isolates from Bangkok, Thailand, between 1994 and 2014 (348 strains), in comparison with regional and global DENV antigenic diversity (64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes increased in similarity, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a trade-off between two types of antigenic change (within-serotype and between-serotype), whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution.

Original language	English (US)
Pages (from-to)	999-1004
Number of pages	6
Journal	Science
Volume	374
Issue number	6570
DOIs	https://doi.org/10.1126/science.abk0058
State	Published - Nov 19 2021
Externally published	Yes

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Katzelnick, L. C., Escoto, A. C., Huang, A. T., Garcia-Carreras, B., Chowdhury, N., Berry, I. M., Chavez, C., Buchy, P., Duong, V., Dussart, P., Gromowski, G., Macareo, L., Thaisomboonsuk, B., Fernandez, S., Smith, D. J., Jarman, R., Whitehead, S. S., Salje, H., & Cummings, D. A. T. (2021). Antigenic evolution of dengue viruses over 20 years. Science, 374(6570), 999-1004. https://doi.org/10.1126/science.abk0058

Katzelnick, LC, Escoto, AC, Huang, AT, Garcia-Carreras, B, Chowdhury, N, Berry, IM, Chavez, C, Buchy, P, Duong, V, Dussart, P, Gromowski, G, Macareo, L, Thaisomboonsuk, B, Fernandez, S, Smith, DJ, Jarman, R, Whitehead, SS, Salje, H & Cummings, DAT 2021, 'Antigenic evolution of dengue viruses over 20 years', Science, vol. 374, no. 6570, pp. 999-1004. https://doi.org/10.1126/science.abk0058

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title = "Antigenic evolution of dengue viruses over 20 years",

abstract = "Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcg receptor{\textendash}bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944 sequenced isolates from Bangkok, Thailand, between 1994 and 2014 (348 strains), in comparison with regional and global DENV antigenic diversity (64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes increased in similarity, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a trade-off between two types of antigenic change (within-serotype and between-serotype), whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution.",

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doi = "10.1126/science.abk0058",

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AU - Berry, Irina Maljkovic

AU - Chavez, Chris

AU - Buchy, Philippe

AU - Duong, Veasna

AU - Dussart, Philippe

AU - Gromowski, Gregory

AU - Macareo, Louis

AU - Thaisomboonsuk, Butsaya

AU - Fernandez, Stefan

AU - Smith, Derek J.

AU - Jarman, Richard

AU - Whitehead, Stephen S.

AU - Salje, Henrik

AU - Cummings, Derek A.T.

PY - 2021/11/19

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N2 - Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcg receptor–bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944 sequenced isolates from Bangkok, Thailand, between 1994 and 2014 (348 strains), in comparison with regional and global DENV antigenic diversity (64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes increased in similarity, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a trade-off between two types of antigenic change (within-serotype and between-serotype), whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution.

AB - Infection with one of dengue viruses 1 to 4 (DENV1-4) induces protective antibodies against homotypic infection. However, a notable feature of dengue viruses is the ability to use preexisting heterotypic antibodies to infect Fcg receptor–bearing immune cells, leading to higher viral load and immunopathological events that augment disease. We tracked the antigenic dynamics of each DENV serotype by using 1944 sequenced isolates from Bangkok, Thailand, between 1994 and 2014 (348 strains), in comparison with regional and global DENV antigenic diversity (64 strains). Over the course of 20 years, the Thailand DENV serotypes gradually evolved away from one another. However, for brief periods, the serotypes increased in similarity, with corresponding changes in epidemic magnitude. Antigenic evolution within a genotype involved a trade-off between two types of antigenic change (within-serotype and between-serotype), whereas genotype replacement resulted in antigenic change away from all serotypes. These findings provide insights into theorized dynamics in antigenic evolution.

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Antigenic evolution of dengue viruses over 20 years

Abstract

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