Antigenic and enzymatic changes in infected and transformed human diploid cells

N. R. Rose, V. Milisauskas, G. Zeff

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Human diploid fibroblasts, WI-38, were infected with various agents and the levels of lysosomal enzymes determined by immunochemical quantitation. Esterase levels were raised by mumps virus and Toxoplasma gondii infection. The concentration of βD-glucuronidase was reduced by these same agents. βD-N-acetyl glucosaminidase was greatly increased in cultures infected with T, gondii and decreased by mycoplasma infection. Two cultures transformed by SV40 showed reduced levels of esterase compared with WI-38, as did one of two transformed amnion cultures. A second amnion culture and a culture of transformed Detroit 551 fibroblasts were unchanged. The levels of acid phosphatase were sharply reduced in three of the four SV40 transformed cultures tested.

Original languageEnglish (US)
Pages (from-to)1-16
Number of pages16
JournalImmunological Investigations
Issue number1
StatePublished - 1975
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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