Abstract
Antiepileptic drugs might be effective in the treatment of patients with Posttraumatic Stress Disorder, a condition with unmet pharmacologic needs. We review the literature on the efficacy and tolerability of antiepileptic drugs in Posttraumatic Stress Disorder, both case reports and open studies, as well as controlled studies if available. The results of the studies will be presented together with their methodological limitations (e.g., open trials, use of additional medications, and lack of use of standardized scales for Posttraumatic Stress Disorder). The effects of antiepileptic drugs on kindling, a suggested pathogenesis for Posttraumatic Stress Disorder are overviewed, and suggestions for further research are raised.
Original language | English (US) |
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Pages (from-to) | 225-229 |
Number of pages | 5 |
Journal | Clinical neuropharmacology |
Volume | 25 |
Issue number | 4 |
DOIs | |
State | Published - Aug 12 2002 |
Externally published | Yes |
Keywords
- Antiepileptic drugs
- Controlled studies
- Kindling
- Posttraumatic stress disorder
- Tolerability
ASJC Scopus subject areas
- Pharmacology
- Clinical Neurology
- Pharmacology (medical)