Antiemetic Effect of Dexamethasone

B. Uzzan, A. Chapman, Thomas F. Paine, Maurie Markman, Vivian Sheidler, David S. Ettinger, Shirley A. Quaskey, E. David Mellits

Research output: Contribution to journalLetterpeer-review


To the Editor: Markman et al. showed in a randomized double-blind controlled trial that dexamethasone had a significantly greater antiemetic effect than prochlorperazine in outpatients receiving cancer chemotherapy (Aug. 30 issue).1 The authors used a crossover design for their study, but they do not specify the method they used to determine randomly the order of administration of the two drugs. Even assuming an initially balanced assignment between patients receiving dexamethasone first and those receiving prochlorperazine first, an imbalanced distribution in the group of seven patients who dropped out of the study may have introduced a bias. Patients may have experienced…

Original languageEnglish (US)
Pages (from-to)1576-1577
Number of pages2
JournalNew England Journal of Medicine
Issue number24
StatePublished - Dec 13 1984

ASJC Scopus subject areas

  • Medicine(all)


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