Antidepressants and the Muscarinic Acetylcholine Receptor

Solomon H. Snyder; Henry I. Yamamura

doi:10.1001/archpsyc.1977.01770140126014

Antidepressants and the Muscarinic Acetylcholine Receptor

Solomon H. Snyder, Henry I. Yamamura

School of Medicine

Research output: Contribution to journal › Article › peer-review

313 Scopus citations

Abstract

Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.

Original language	English (US)
Pages (from-to)	236-239
Number of pages	4
Journal	Archives of general psychiatry
Volume	34
Issue number	2
DOIs	https://doi.org/10.1001/archpsyc.1977.01770140126014
State	Published - Feb 1977

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Psychiatry and Mental health

Access to Document

10.1001/archpsyc.1977.01770140126014

Cite this

@article{7482924f137f4c79ae16a1540f9c3084,

title = "Antidepressants and the Muscarinic Acetylcholine Receptor",

abstract = "Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.",

author = "Snyder, {Solomon H.} and Yamamura, {Henry I.}",

year = "1977",

month = feb,

doi = "10.1001/archpsyc.1977.01770140126014",

language = "English (US)",

volume = "34",

pages = "236--239",

journal = "JAMA Psychiatry",

issn = "2168-622X",

publisher = "American Medical Association",

number = "2",

}

TY - JOUR

T1 - Antidepressants and the Muscarinic Acetylcholine Receptor

AU - Snyder, Solomon H.

AU - Yamamura, Henry I.

PY - 1977/2

Y1 - 1977/2

N2 - Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.

AB - Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.

UR - http://www.scopus.com/inward/record.url?scp=0017341989&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017341989&partnerID=8YFLogxK

U2 - 10.1001/archpsyc.1977.01770140126014

DO - 10.1001/archpsyc.1977.01770140126014

M3 - Article

C2 - 14603

AN - SCOPUS:0017341989

SN - 2168-622X

VL - 34

SP - 236

EP - 239

JO - JAMA Psychiatry

JF - JAMA Psychiatry

IS - 2

ER -

Antidepressants and the Muscarinic Acetylcholine Receptor

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this