Antidepressants and the Muscarinic Acetylcholine Receptor

Solomon H. Snyder; Henry I. Yamamura

doi:10.1001/archpsyc.1977.01770140126014

Antidepressants and the Muscarinic Acetylcholine Receptor

Solomon H. Snyder, Henry I. Yamamura

School of Medicine

Research output: Contribution to journal › Article › peer-review

313 Scopus citations

Abstract

Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.

Original language	English (US)
Pages (from-to)	236-239
Number of pages	4
Journal	Archives of general psychiatry
Volume	34
Issue number	2
DOIs	https://doi.org/10.1001/archpsyc.1977.01770140126014
State	Published - Feb 1977

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Psychiatry and Mental health

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10.1001/archpsyc.1977.01770140126014

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abstract = "Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.",

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Antidepressants and the Muscarinic Acetylcholine Receptor

Abstract

ASJC Scopus subject areas

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