Antidepressants and the Muscarinic Acetylcholine Receptor

Solomon H. Snyder, Henry I. Yamamura

Research output: Contribution to journalArticlepeer-review

313 Scopus citations


Several tricyclic antidepressants have been assessed for their potency in binding to the muscarinic acetylcholine receptor of brain and intestine. Amitriptyline hydrochloride is about ten times as potent as imipramine hydrochloride. Dimethylated drugs are more potent than monomethylated ones. The relative anticholinergic activities of tricyclic antidepressants have implications for their use in patients who might be affected adversely by anticholinergic effects.

Original languageEnglish (US)
Pages (from-to)236-239
Number of pages4
JournalArchives of general psychiatry
Issue number2
StatePublished - Feb 1977

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health


Dive into the research topics of 'Antidepressants and the Muscarinic Acetylcholine Receptor'. Together they form a unique fingerprint.

Cite this