Antidepressant use during pregnancy: Current controversies and treatment strategies

Jennifer L. Payne, Samantha Meltzer-Brody

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations


The treatment of depression during pregnancy is both a common and complex clinical challenge. The decision to expose the fetus to antidepressant medication during pregnancy must be weighed against the risks of untreated maternal depression to both mother and fetus. Maternal depression during pregnancy has been associated with increased rates of preterm birth and maternal substance use. The safety of antidepressant use during pregnancy seems to be largely reassuring but there remain 2 areas of controversy including neonatal withdrawal syndrome and primary pulmonary hypertension of the newborn. Individualized treatment recommendations based on the patient's history are essential to optimize outcomes.

Original languageEnglish (US)
Pages (from-to)469-482
Number of pages14
JournalClinical obstetrics and gynecology
Issue number3
StatePublished - Sep 2009
Externally publishedYes


  • Antidepressants
  • Depression
  • Neonatal withdrawal syndrome
  • PPHN
  • Pregnancy
  • Safety

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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