Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice

Soichiro Ide; Shunsuke Fujiwara; Masayuki Fujiwara; Ichiro Sora; Kazutaka Ikeda; Masabumi Minami; George R. Uhl; Kumatoshi Ishihara

doi:10.1254/jphs.10136SC

Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice

Soichiro Ide, Shunsuke Fujiwara, Masayuki Fujiwara, Ichiro Sora, Kazutaka Ikeda, Masabumi Minami, George R. Uhl, Kumatoshi Ishihara

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO) mice. Venlafaxine reduced immobility time in wildtype mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressantlike effects of venlafaxine.

Original language	English (US)
Pages (from-to)	107-110
Number of pages	4
Journal	Journal of Pharmacological Sciences
Volume	114
Issue number	1
DOIs	https://doi.org/10.1254/jphs.10136SC
State	Published - 2010
Externally published	Yes

Keywords

μ-opioid receptor
Antidepressant
Knockout mouse

ASJC Scopus subject areas

Pharmacology
Molecular Medicine

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10.1254/jphs.10136SC

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title = "Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice",

abstract = "Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO) mice. Venlafaxine reduced immobility time in wildtype mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressantlike effects of venlafaxine.",

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doi = "10.1254/jphs.10136SC",

language = "English (US)",

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T1 - Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice

AU - Ide, Soichiro

AU - Fujiwara, Shunsuke

AU - Fujiwara, Masayuki

AU - Sora, Ichiro

AU - Ikeda, Kazutaka

AU - Minami, Masabumi

AU - Uhl, George R.

AU - Ishihara, Kumatoshi

PY - 2010

Y1 - 2010

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AB - Although the opioid system is known to modulate depression-like behaviors, its role in the effects of antidepressants is not yet clear. We investigated the role of μ-opioid receptors (MOPs) in the effects of venlafaxine, a serotonin and norepinephrine reuptake inhibitor, in the forced swim test using MOP-knockout (KO) mice. Venlafaxine reduced immobility time in wildtype mice (C57BL/6J), but not in MOP-KO mice, although no significant effects were observed on locomotor activity. These results suggest that MOPs play an important role in the antidepressantlike effects of venlafaxine.

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KW - Antidepressant

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Antidepressant-like effect of venlafaxine is abolished in μ-opioid receptor-knockout mice

Abstract

Keywords

ASJC Scopus subject areas

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