Antibrain antibodies in children with autism and their unaffected siblings

Harvey S. Singer; Christina M. Morris; Phillip N. Williams; Dustin Y. Yoon; John J. Hong; Andrew W. Zimmerman

doi:10.1016/j.jneuroim.2006.05.025

Antibrain antibodies in children with autism and their unaffected siblings

Harvey S. Singer, Christina M. Morris, Phillip N. Williams, Dustin Y. Yoon, John J. Hong, Andrew W. Zimmerman

School of Medicine

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Serum autoantibodies to human brain, identified by ELISA and Western immunoblotting, were evaluated in 29 children with autism spectrum disorder (22 with autistic disorder), 9 non-autistic siblings and 13 controls. More autistic subjects than controls had bands at 100 kDa in caudate, putamen and prefrontal cortex (p < 0.01) as well as larger peak heights of bands at 73 kDa in the cerebellum and cingulate gyrus. Both autistic disorder subjects and their matched non-autistic siblings had denser bands (peak height and/or area under the curve) at 73 kDa in the cerebellum and cingulate gyrus than did controls (p < 0.01). Results suggest that children with autistic disorder and their siblings exhibit differences compared to controls in autoimmune reactivity to specific epitopes located in distinct brain regions.

Original language	English (US)
Pages (from-to)	149-155
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	178
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2006.05.025
State	Published - Sep 2006

Keywords

100 kDa
73 kDa
Autism
Autoantibodies
Immunoblotting
Siblings

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2006.05.025

Cite this

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title = "Antibrain antibodies in children with autism and their unaffected siblings",

abstract = "Serum autoantibodies to human brain, identified by ELISA and Western immunoblotting, were evaluated in 29 children with autism spectrum disorder (22 with autistic disorder), 9 non-autistic siblings and 13 controls. More autistic subjects than controls had bands at 100 kDa in caudate, putamen and prefrontal cortex (p < 0.01) as well as larger peak heights of bands at 73 kDa in the cerebellum and cingulate gyrus. Both autistic disorder subjects and their matched non-autistic siblings had denser bands (peak height and/or area under the curve) at 73 kDa in the cerebellum and cingulate gyrus than did controls (p < 0.01). Results suggest that children with autistic disorder and their siblings exhibit differences compared to controls in autoimmune reactivity to specific epitopes located in distinct brain regions.",

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T1 - Antibrain antibodies in children with autism and their unaffected siblings

AU - Singer, Harvey S.

AU - Morris, Christina M.

AU - Williams, Phillip N.

AU - Yoon, Dustin Y.

AU - Hong, John J.

AU - Zimmerman, Andrew W.

PY - 2006/9

Y1 - 2006/9

N2 - Serum autoantibodies to human brain, identified by ELISA and Western immunoblotting, were evaluated in 29 children with autism spectrum disorder (22 with autistic disorder), 9 non-autistic siblings and 13 controls. More autistic subjects than controls had bands at 100 kDa in caudate, putamen and prefrontal cortex (p < 0.01) as well as larger peak heights of bands at 73 kDa in the cerebellum and cingulate gyrus. Both autistic disorder subjects and their matched non-autistic siblings had denser bands (peak height and/or area under the curve) at 73 kDa in the cerebellum and cingulate gyrus than did controls (p < 0.01). Results suggest that children with autistic disorder and their siblings exhibit differences compared to controls in autoimmune reactivity to specific epitopes located in distinct brain regions.

AB - Serum autoantibodies to human brain, identified by ELISA and Western immunoblotting, were evaluated in 29 children with autism spectrum disorder (22 with autistic disorder), 9 non-autistic siblings and 13 controls. More autistic subjects than controls had bands at 100 kDa in caudate, putamen and prefrontal cortex (p < 0.01) as well as larger peak heights of bands at 73 kDa in the cerebellum and cingulate gyrus. Both autistic disorder subjects and their matched non-autistic siblings had denser bands (peak height and/or area under the curve) at 73 kDa in the cerebellum and cingulate gyrus than did controls (p < 0.01). Results suggest that children with autistic disorder and their siblings exhibit differences compared to controls in autoimmune reactivity to specific epitopes located in distinct brain regions.

KW - 100 kDa

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KW - Autism

KW - Autoantibodies

KW - Immunoblotting

KW - Siblings

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Antibrain antibodies in children with autism and their unaffected siblings

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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