Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

C. T. Kyngdon; C. G. Gauci; A. E. Gonzalez; A. Flisser; A. Zoli; A. J. Read; J. Martínez-Ocaña; R. A. Strugnell; M. W. Lightowlers

doi:10.1111/j.1365-3024.2006.00820.x

Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

C. T. Kyngdon, C. G. Gauci, A. E. Gonzalez, A. Flisser, A. Zoli, A. J. Read, J. Martínez-Ocaña, R. A. Strugnell, M. W. Lightowlers

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22 Scopus citations

Abstract

Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species.

Original language	English (US)
Pages (from-to)	191-199
Number of pages	9
Journal	Parasite Immunology
Volume	28
Issue number	5
DOIs	https://doi.org/10.1111/j.1365-3024.2006.00820.x
State	Published - May 2006
Externally published	Yes

Keywords

Epitopes
Fibronectin
TSOL18
TSOL45-1A
Taenia solium

ASJC Scopus subject areas

Parasitology
Immunology

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10.1111/j.1365-3024.2006.00820.x

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title = "Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A",

abstract = "Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species.",

keywords = "Epitopes, Fibronectin, TSOL18, TSOL45-1A, Taenia solium",

author = "Kyngdon, {C. T.} and Gauci, {C. G.} and Gonzalez, {A. E.} and A. Flisser and A. Zoli and Read, {A. J.} and J. Mart{\'i}nez-Oca{\~n}a and Strugnell, {R. A.} and Lightowlers, {M. W.}",

year = "2006",

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language = "English (US)",

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AU - Kyngdon, C. T.

AU - Gauci, C. G.

AU - Gonzalez, A. E.

AU - Flisser, A.

AU - Zoli, A.

AU - Read, A. J.

AU - Martínez-Ocaña, J.

AU - Strugnell, R. A.

AU - Lightowlers, M. W.

PY - 2006/5

Y1 - 2006/5

N2 - Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species.

AB - Taenia solium is a cestode parasite that causes cysticercosis in humans and pigs. This study examined the antibody responses in pigs immunized with the TSOL18 and TSOL45-1A recombinant vaccines against T. solium cysticercosis. Immunization with these proteins induced specific, complement-fixing antibodies against the recombinant antigens that are believed to be associated with vaccine-induced protection against T. solium infection. Sera from immunized pigs were used to define the linear B-cell epitopes of TSOL18 and TSOL45-1A. Prominent reactivity was revealed to one linear epitope on TSOL18 and two linear epitopes on TSOL45-1A. These, and oncosphere antigens from other taeniid cestodes, contain a protein sequence motif suggesting that they may show a tertiary structure similar to the fibronectin type III domain (FnIII). Comparison of the location of linear antigenic epitopes in TSOL18 and TSOL45-1A within the proposed FnIII structure to those within related cestode vaccine antigens reveals conservation in the positioning of the epitopes between oncosphere antigens from different taeniid species.

KW - Epitopes

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KW - TSOL18

KW - TSOL45-1A

KW - Taenia solium

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Antibody responses and epitope specificities to the Taenia solium cysticercosis vaccines TSOL18 and TSOL45-1A

Abstract

Keywords

ASJC Scopus subject areas

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