Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice

Maria E. Lorenzo; Andrea Hodgson; Dionne P. Robinson; Jenifer B. Kaplan; Andrew Pekosz; Sabra L. Klein

doi:10.1016/j.vaccine.2011.09.110

Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice

Maria E. Lorenzo, Andrea Hodgson, Dionne P. Robinson, Jenifer B. Kaplan, Andrew Pekosz, Sabra L. Klein

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naïve females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge.

Original language	English (US)
Pages (from-to)	9246-9255
Number of pages	10
Journal	Vaccine
Volume	29
Issue number	49
DOIs	https://doi.org/10.1016/j.vaccine.2011.09.110
State	Published - Nov 15 2011

Keywords

Humoral immunity
Influenza vaccine
Sex difference

ASJC Scopus subject areas

Molecular Medicine
Immunology and Microbiology(all)
veterinary(all)
Public Health, Environmental and Occupational Health
Infectious Diseases

Access to Document

10.1016/j.vaccine.2011.09.110

Cite this

@article{2b2b2aa843a142efb8c863dffc668a50,

title = "Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice",

abstract = "A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for na{\"i}ve females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge.",

keywords = "Humoral immunity, Influenza vaccine, Sex difference",

author = "Lorenzo, {Maria E.} and Andrea Hodgson and Robinson, {Dionne P.} and Kaplan, {Jenifer B.} and Andrew Pekosz and Klein, {Sabra L.}",

note = "Funding Information: We thank Shaun Stewart for technical assistance. Support for this study was provided by NIH AI079342 and AI090344 , an award from Marjorie Gilbert, and a Medtronic SWHR award. ",

year = "2011",

month = nov,

day = "15",

doi = "10.1016/j.vaccine.2011.09.110",

language = "English (US)",

volume = "29",

pages = "9246--9255",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier BV",

number = "49",

}

TY - JOUR

T1 - Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice

AU - Lorenzo, Maria E.

AU - Hodgson, Andrea

AU - Robinson, Dionne P.

AU - Kaplan, Jenifer B.

AU - Pekosz, Andrew

AU - Klein, Sabra L.

N1 - Funding Information: We thank Shaun Stewart for technical assistance. Support for this study was provided by NIH AI079342 and AI090344 , an award from Marjorie Gilbert, and a Medtronic SWHR award.

PY - 2011/11/15

Y1 - 2011/11/15

N2 - A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naïve females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge.

AB - A mouse model was used to determine if protective immunity to influenza A virus infection differs between the sexes. The median lethal dose of H1N1 or H3N2 was lower for naïve females than males. After a sublethal, primary infection with H1N1 or H3N2, females and males showed a similar transient morbidity, but females generated more neutralizing and total anti-influenza A virus antibodies. Immunized males and females showed similar protection against secondary challenge with a homologous virus, but males experienced greater morbidity and had higher lung viral titers after infection with a lethal dose of heterologous virus. Females develop stronger humoral immune responses and greater cross protection against heterosubtypic virus challenge.

KW - Humoral immunity

KW - Influenza vaccine

KW - Sex difference

UR - http://www.scopus.com/inward/record.url?scp=82555165812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82555165812&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2011.09.110

DO - 10.1016/j.vaccine.2011.09.110

M3 - Article

C2 - 21983155

AN - SCOPUS:82555165812

SN - 0264-410X

VL - 29

SP - 9246

EP - 9255

JO - Vaccine

JF - Vaccine

IS - 49

ER -

Antibody responses and cross protection against lethal influenza A viruses differ between the sexes in C57BL/6 mice

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this