Antibody mediated suppression of lymphoma: participation of platelets, lymphocytes, and nonphagocytic macrophages

H. S. Shin, M. L. Hayden, C. L. Gately

Research output: Contribution to journalArticlepeer-review

Abstract

Humoral antibody directed against a grafted murine lymphoma can suppress the growth of the tumor in mice of the inbred strain native to the tumor. Antibody, however, cannot suppress the tumor growth in mice given 500 R of whole body irradiation. When the tumor antibody inoculum is admixed with lymphocytes or macrophages obtained from peritoneal exudate, macrophages experimentally rendered nonphagocytic, or with platelets isolated from peripheral blood, the tumor growth is suppressed in irradiated mice. These results indicate that mechanisms other than phagocytosis may play an important role in antibody mediated suppression of tumor growth in vivo.

Original languageEnglish (US)
Pages (from-to)163-166
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Volume71
Issue number1
DOIs
StatePublished - 1974

ASJC Scopus subject areas

  • General

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