Abstract
An antibody-dependent cell-mediated cytotoxicity (ADCC) assay was utilized to measure null cell function in 37 patients with cutaneous lymphomas including mycosis fungoides (NM and Sezary syndrome. Five patients with psoriasis vulgaris were included as controls for benign dermatologic disease. Patients with MF, non-MF cutaneous lymphomas, and psoriasis had mean ADCC levels equal to or greater than control values, while patients with Sézary syndrome had significantly depressed levels (64% of control values). Although this study did not explain the reason for the depression, it indicated that the ADCC assay may prove useful as a prognostic tool and as an additional means of identifying Sezary syndrome.
Original language | English (US) |
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Pages (from-to) | 609-613 |
Number of pages | 5 |
Journal | International Journal of Radiation Oncology, Biology, Physics |
Volume | 4 |
Issue number | 7-8 |
DOIs | |
State | Published - 1978 |
Externally published | Yes |
Keywords
- Antibody-dependent cell-mediated cytotoxicity
- Mycosis fungoides
- Sezary syndrome
ASJC Scopus subject areas
- Oncology
- Radiology Nuclear Medicine and imaging
- Radiation