Abstract
Historically there has been controversy on the relative importance of antibody- and cell-mediated immune responses in the protection against fungal pathogens. The controversy was fuelled by the difficulties encountered in obtaining consistent results with polyclonal antibody experiments and I inducing long-lasting immune protection by vaccinations with induce stron cell-mediated responses. Recent studies indicate that both antibody- and cell-mediated immune responses can contribute to host protection against Candida albicans and C. neoformans. At the present time the major issue is not the relative importance of antibody- and cell-mediated immune responses but rather, the mechanisms by which the two arms of the immune system function and cooperate.
Original language | English (US) |
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Pages (from-to) | 95-105 |
Number of pages | 11 |
Journal | Medical Mycology, Supplement |
Volume | 36 |
Issue number | 1 |
State | Published - 1998 |
Externally published | Yes |
Keywords
- Antibody
- Candida albicans
- Cell-mediated immunity
- Cryptococcus neoformans
- Humoral immunity
- T cell
- Vaccine
ASJC Scopus subject areas
- Microbiology
- Immunology