Antibiotic resistance and serotype distribution of Streptococcus pneumoniae colonizing rural Malawian children

Daniel R. Feikin; Mollie Davis; Okey C. Nwanyanwu; Peter N. Kazembe; Lawrence M. Barat; Avril Wasas; Peter B. Bloland; Charles Ziba; Thora Capper; Robin E. Huebner; Ben Schwartz; Keith P. Klugman; Scott F. Dowell

doi:10.1097/01.inf.0000069787.33960.d6

Antibiotic resistance and serotype distribution of Streptococcus pneumoniae colonizing rural Malawian children

Daniel R. Feikin, Mollie Davis, Okey C. Nwanyanwu, Peter N. Kazembe, Lawrence M. Barat, Avril Wasas, Peter B. Bloland, Charles Ziba, Thora Capper, Robin E. Huebner, Ben Schwartz, Keith P. Klugman, Scott F. Dowell

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Nasopharyngeal swabs were taken from 906 Malawian children <5 years old visiting rural health clinics. Pneumococcal colonization was high, 84% among all children, and occurred early, 65% of it in children <3 months old. Among pneumococcal isolates 46% were nonsusceptible to trimethoprim-sulfamethoxazole, and 21% were nonsusceptible to penicillin. Trimethoprim-sulfamethoxazole use in the previous month was a risk factor for trimethoprim-sulfamethoxazole and penicillin non-susceptibility. Forty-three percent of isolates were serotypes included in the 7-valent pneumococcal conjugate vaccine, and 37% were vaccine-related serotypes, particularly 6A and 19A.

Original language	English (US)
Pages (from-to)	564-567
Number of pages	4
Journal	Pediatric Infectious Disease Journal
Volume	22
Issue number	6
DOIs	https://doi.org/10.1097/01.inf.0000069787.33960.d6
State	Published - Jun 1 2003
Externally published	Yes

Keywords

Antibiotic resistance
Malawi
Pneumococcus
Serotypes

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/01.inf.0000069787.33960.d6

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Feikin, D. R., Davis, M., Nwanyanwu, O. C., Kazembe, P. N., Barat, L. M., Wasas, A., Bloland, P. B., Ziba, C., Capper, T., Huebner, R. E., Schwartz, B., Klugman, K. P., & Dowell, S. F. (2003). Antibiotic resistance and serotype distribution of Streptococcus pneumoniae colonizing rural Malawian children. Pediatric Infectious Disease Journal, 22(6), 564-567. https://doi.org/10.1097/01.inf.0000069787.33960.d6

Feikin, DR, Davis, M, Nwanyanwu, OC, Kazembe, PN, Barat, LM, Wasas, A, Bloland, PB, Ziba, C, Capper, T, Huebner, RE, Schwartz, B, Klugman, KP & Dowell, SF 2003, 'Antibiotic resistance and serotype distribution of Streptococcus pneumoniae colonizing rural Malawian children', Pediatric Infectious Disease Journal, vol. 22, no. 6, pp. 564-567. https://doi.org/10.1097/01.inf.0000069787.33960.d6

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abstract = "Nasopharyngeal swabs were taken from 906 Malawian children <5 years old visiting rural health clinics. Pneumococcal colonization was high, 84% among all children, and occurred early, 65% of it in children <3 months old. Among pneumococcal isolates 46% were nonsusceptible to trimethoprim-sulfamethoxazole, and 21% were nonsusceptible to penicillin. Trimethoprim-sulfamethoxazole use in the previous month was a risk factor for trimethoprim-sulfamethoxazole and penicillin non-susceptibility. Forty-three percent of isolates were serotypes included in the 7-valent pneumococcal conjugate vaccine, and 37% were vaccine-related serotypes, particularly 6A and 19A.",

keywords = "Antibiotic resistance, Malawi, Pneumococcus, Serotypes",

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AU - Kazembe, Peter N.

AU - Barat, Lawrence M.

AU - Wasas, Avril

AU - Bloland, Peter B.

AU - Ziba, Charles

AU - Capper, Thora

AU - Huebner, Robin E.

AU - Schwartz, Ben

AU - Klugman, Keith P.

AU - Dowell, Scott F.

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AB - Nasopharyngeal swabs were taken from 906 Malawian children <5 years old visiting rural health clinics. Pneumococcal colonization was high, 84% among all children, and occurred early, 65% of it in children <3 months old. Among pneumococcal isolates 46% were nonsusceptible to trimethoprim-sulfamethoxazole, and 21% were nonsusceptible to penicillin. Trimethoprim-sulfamethoxazole use in the previous month was a risk factor for trimethoprim-sulfamethoxazole and penicillin non-susceptibility. Forty-three percent of isolates were serotypes included in the 7-valent pneumococcal conjugate vaccine, and 37% were vaccine-related serotypes, particularly 6A and 19A.

KW - Antibiotic resistance

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KW - Pneumococcus

KW - Serotypes

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Antibiotic resistance and serotype distribution of Streptococcus pneumoniae colonizing rural Malawian children

Abstract

Keywords

ASJC Scopus subject areas

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