Antibiotic prophylaxis for cardiovascular surgery. Efficacy with coronary artery bypass

R. Platt, A. Munoz, J. Stella, S. VanDevanter, J. K. Koster

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


Two hundred twenty patients were randomly assigned to receive either ceforanide or cephalothin as perioperative antibiotic prophylaxis during cardiovascular surgery. More infections were seen among cephalothin recipients (8 deep, 32 total) then among ceforanide recipients (1 deep, 17 total). Among patients who had only coronary artery bypass grafting, more cephalothin recipients had infection than did ceforanide recipients (19 of 82 as opposed to 7 of 83; p = 0.001; relative risk, 2.7; 95% confidence interval, 1.22 to 6.18). The difference between the two regimens was attributable to fewer blood, wound, and urinary tract infections. Among patients who had other procedures, there was no difference in the efficacy of the two regimens. Cephalothin recipients who developed wound or blood stream infections had lower antibiotic levels in their atrial appendages than recipients not developing such infections (p = 0.02). If one assumes that cephalothin does not increase the risk of infection, then these data show that antibiotic prophylaxis prevents infection after coronary artery bypass surgery, and, in the dosages used, that ceforanide is superior to cephalothin.

Original languageEnglish (US)
Pages (from-to)770-774
Number of pages5
JournalAnnals of internal medicine
Issue number6
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Internal Medicine


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