ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN

G. D. Rifkin; F. R. Fekety; J. Silva; R. B. Sack

doi:10.1016/S0140-6736(77)90547-5

ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN

G. D. Rifkin, F. R. Fekety, J. Silva, R. B. Sack

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160 Scopus citations

Abstract

A toxin(s) has been demonstrated in the stools of two patients with antibiotic- associated colitis. This toxin(s) was heat-labile, wasrapidly lethal for hamsters, increased vascular permeability in rabbit skin, and was cytotoxic for cells in tissue-culture. It was neutralised by Clostridium sordellii antitoxin but not by antitoxins prepared against otherclostridia; Escherichia coli, and Vibrio cholerœ toxins. These characteristics were identical to those of a toxin implicated in the ætiology of antibiotic-induced colitis in the hamster. One patient improved rapidly after treatment with oral vancomycin, and at the same time the toxin disappeared from the stool.

Original language	English (US)
Pages (from-to)	1103-1106
Number of pages	4
Journal	The Lancet
Volume	310
Issue number	8048
DOIs	https://doi.org/10.1016/S0140-6736(77)90547-5
State	Published - Nov 26 1977
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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@article{362f3f9d550d456d957929ee07340452,

title = "ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN",

abstract = "A toxin(s) has been demonstrated in the stools of two patients with antibiotic- associated colitis. This toxin(s) was heat-labile, wasrapidly lethal for hamsters, increased vascular permeability in rabbit skin, and was cytotoxic for cells in tissue-culture. It was neutralised by Clostridium sordellii antitoxin but not by antitoxins prepared against otherclostridia; Escherichia coli, and Vibrio choler{\oe} toxins. These characteristics were identical to those of a toxin implicated in the {\ae}tiology of antibiotic-induced colitis in the hamster. One patient improved rapidly after treatment with oral vancomycin, and at the same time the toxin disappeared from the stool.",

author = "Rifkin, {G. D.} and Fekety, {F. R.} and J. Silva and Sack, {R. B.}",

note = "Funding Information: This study was supported by the Frederick Novy Infectious Disease Research Fund and by the Upjohn Company, Kalamazoo, Michigan Requests for reprints should be addressed to: G. D. R., Division oj U.S.A.Infectious Diseases, University Hospital, Ann Arbor, Michigan 48109",

year = "1977",

month = nov,

day = "26",

doi = "10.1016/S0140-6736(77)90547-5",

language = "English (US)",

volume = "310",

pages = "1103--1106",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Limited",

number = "8048",

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T1 - ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN

AU - Rifkin, G. D.

AU - Fekety, F. R.

AU - Silva, J.

AU - Sack, R. B.

N1 - Funding Information: This study was supported by the Frederick Novy Infectious Disease Research Fund and by the Upjohn Company, Kalamazoo, Michigan Requests for reprints should be addressed to: G. D. R., Division oj U.S.A.Infectious Diseases, University Hospital, Ann Arbor, Michigan 48109

PY - 1977/11/26

Y1 - 1977/11/26

N2 - A toxin(s) has been demonstrated in the stools of two patients with antibiotic- associated colitis. This toxin(s) was heat-labile, wasrapidly lethal for hamsters, increased vascular permeability in rabbit skin, and was cytotoxic for cells in tissue-culture. It was neutralised by Clostridium sordellii antitoxin but not by antitoxins prepared against otherclostridia; Escherichia coli, and Vibrio cholerœ toxins. These characteristics were identical to those of a toxin implicated in the ætiology of antibiotic-induced colitis in the hamster. One patient improved rapidly after treatment with oral vancomycin, and at the same time the toxin disappeared from the stool.

AB - A toxin(s) has been demonstrated in the stools of two patients with antibiotic- associated colitis. This toxin(s) was heat-labile, wasrapidly lethal for hamsters, increased vascular permeability in rabbit skin, and was cytotoxic for cells in tissue-culture. It was neutralised by Clostridium sordellii antitoxin but not by antitoxins prepared against otherclostridia; Escherichia coli, and Vibrio cholerœ toxins. These characteristics were identical to those of a toxin implicated in the ætiology of antibiotic-induced colitis in the hamster. One patient improved rapidly after treatment with oral vancomycin, and at the same time the toxin disappeared from the stool.

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DO - 10.1016/S0140-6736(77)90547-5

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AN - SCOPUS:0017784215

SN - 0140-6736

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JO - The Lancet

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IS - 8048

ER -

ANTIBIOTIC-INDUCED COLITIS IMPLICATION OF A TOXIN NEUTRALISED BY CLOSTRIDIUM SORDELLII ANTITOXIN

Abstract

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