@article{bd13b570919746b796c6303ff722003a,
title = "Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission",
abstract = "Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Queque{\~n}a, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.",
keywords = "Antibody response, Impregnated net, Saliva, Sentinel guinea pig, Triatoma infestans",
author = "Alexandra Schwarz and Juarez, {Jenny Ancca} and Jean Richards and Bruno Rath and Machaca, {Victor Quispe} and Castro, {Yagahira E.} and M{\'a}laga, {Edith S.} and Katelyn Levy and Gilman, {Robert H.} and Caryn Bern and Manuela Verastegui and Levy, {Michael Z.}",
note = "Funding Information: We thank the community of Queque{\~n}a for their participation. We especially thank Rocio Rodriguez, Amparo Toledo and the sprayers and field collectors who worked on the study. We also thank Gregory Martin, Jeffrey Stancil, David Bentzel, Ellen Dotson, Robert Wirtz, Lucy Rubio, Gena Lawrence, Karina Oppe and Fernando Malaga for assistance and support. The authors thank Torben Frandsen for fabrication and donation of the guinea pig PermaNets, and Jesus Valenzuela for his advice and support. We would also like to thank the Pan American Health Organization (PAHO), the Canadian International Development Agency (CIDA), Ministerio de Salud del Per{\'u} (MINSA), Direcci{\'o}n General de Salud de las Personas (DGSP), Estrategia Sanitaria Nacional de Prevenci{\'o}n y Control de Enfermedades Metax{\'e}nicas y Otras Transmitidas por Vectores (ESNPCEMOTVS), Direcci{\'o}n General de Salud Ambiental (DIGESA), Gobierno Regional de Arequipa and the Gerencia Regional de Salud de Arequipa (GRSA). Funding for this study came from NIH 5K01 AI079162-03, NIH 3K01AI079162-02S1, 3K01AI079162-03S1 and NIH P50 AI074285-04. This study also received financial support from the UNICEF/UNDP/World Bank/WHO Special Program for Research and Training in Tropical Diseases (TDR Grant) and the Grant Agency of the Czech Republic , Grant No. P302/11/P798 .",
year = "2011",
month = may,
doi = "10.1016/j.ijpara.2011.02.001",
language = "English (US)",
volume = "41",
pages = "591--594",
journal = "International Journal for Parasitology",
issn = "0020-7519",
publisher = "Elsevier Limited",
number = "6",
}