Anti-triatomine saliva immunoassays for the evaluation of impregnated netting trials against Chagas disease transmission

Alexandra Schwarz, Jenny Ancca Juarez, Jean Richards, Bruno Rath, Victor Quispe Machaca, Yagahira E. Castro, Edith S. Málaga, Katelyn Levy, Robert H. Gilman, Caryn Bern, Manuela Verastegui, Michael Z. Levy

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Insecticide-impregnated nets can kill triatomine bugs, but it remains unclear whether they can protect against Chagas disease transmission. In a field trial in Quequeña, Peru, sentinel guinea pigs placed in intervention enclosures covered by deltamethrin-treated nets showed significantly lower antibody responses to saliva of Triatoma infestans compared with animals placed in pre-existing control enclosures. Our results strongly suggest that insecticide-treated nets prevent triatomine bites and can thereby protect against infection with Trypanosoma cruzi. Anti-salivary immunoassays are powerful new tools to evaluate intervention strategies against Chagas disease.

Original languageEnglish (US)
Pages (from-to)591-594
Number of pages4
JournalInternational Journal for Parasitology
Volume41
Issue number6
DOIs
StatePublished - May 2011

Keywords

  • Antibody response
  • Impregnated net
  • Saliva
  • Sentinel guinea pig
  • Triatoma infestans

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases

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