Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Dong Gun Lee; Yoonkyung Park; Mi Ran Kim; Hyun Jun Jung; Young Bae Seu; Kyung Soo Hahm; Eun Rhan Woo

doi:10.1023/B:BILE.0000035483.85790.f7

Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Dong Gun Lee, Yoonkyung Park, Mi Ran Kim, Hyun Jun Jung, Young Bae Seu, Kyung Soo Hahm, Eun Rhan Woo

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml ^-1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml ^-1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

Original language	English (US)
Pages (from-to)	1125-1130
Number of pages	6
Journal	Biotechnology Letters
Volume	26
Issue number	14
DOIs	https://doi.org/10.1023/B:BILE.0000035483.85790.f7
State	Published - Jul 2004
Externally published	Yes

Keywords

Lycium chinense
Solanaceae
anti-fungal activity
dihydro-N-caffeoyltyramine
trans-N-caffeoyltyramine
trans-N-feruloyloctopamine

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology

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10.1023/B:BILE.0000035483.85790.f7

Cite this

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title = "Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense",

abstract = "Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml -1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml -1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.",

keywords = "Lycium chinense, Solanaceae, anti-fungal activity, dihydro-N-caffeoyltyramine, trans-N-caffeoyltyramine, trans-N-feruloyloctopamine",

author = "Lee, {Dong Gun} and Yoonkyung Park and Kim, {Mi Ran} and Jung, {Hyun Jun} and Seu, {Young Bae} and Hahm, {Kyung Soo} and Woo, {Eun Rhan}",

note = "Funding Information: This work was supported by the Korean Ministry of Science and Technology, the Korean Science and Engineering Foundation through the Research Center for Proteineous Materials. We thank the Gwangju Branch of the Korea Basic Science Institute (KBSI) for running the NMR experiments.",

year = "2004",

month = jul,

doi = "10.1023/B:BILE.0000035483.85790.f7",

language = "English (US)",

volume = "26",

pages = "1125--1130",

journal = "Biotechnology Letters",

issn = "0141-5492",

publisher = "Springer Netherlands",

number = "14",

}

TY - JOUR

T1 - Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

AU - Lee, Dong Gun

AU - Park, Yoonkyung

AU - Kim, Mi Ran

AU - Jung, Hyun Jun

AU - Seu, Young Bae

AU - Hahm, Kyung Soo

AU - Woo, Eun Rhan

N1 - Funding Information: This work was supported by the Korean Ministry of Science and Technology, the Korean Science and Engineering Foundation through the Research Center for Proteineous Materials. We thank the Gwangju Branch of the Korea Basic Science Institute (KBSI) for running the NMR experiments.

PY - 2004/7

Y1 - 2004/7

N2 - Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml -1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml -1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

AB - Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml -1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml -1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

KW - Lycium chinense

KW - Solanaceae

KW - anti-fungal activity

KW - dihydro-N-caffeoyltyramine

KW - trans-N-caffeoyltyramine

KW - trans-N-feruloyloctopamine

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U2 - 10.1023/B:BILE.0000035483.85790.f7

DO - 10.1023/B:BILE.0000035483.85790.f7

M3 - Article

C2 - 15266117

AN - SCOPUS:3943093345

SN - 0141-5492

VL - 26

SP - 1125

EP - 1130

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 14

ER -

Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Abstract

Keywords

ASJC Scopus subject areas

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