Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Dong Gun Lee, Yoonkyung Park, Mi Ran Kim, Hyun Jun Jung, Young Bae Seu, Kyung Soo Hahm, Eun Rhan Woo

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N- feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5-10 μg ml -1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml -1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

Original languageEnglish (US)
Pages (from-to)1125-1130
Number of pages6
JournalBiotechnology Letters
Issue number14
StatePublished - Jul 2004
Externally publishedYes


  • Lycium chinense
  • Solanaceae
  • anti-fungal activity
  • dihydro-N-caffeoyltyramine
  • trans-N-caffeoyltyramine
  • trans-N-feruloyloctopamine

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


Dive into the research topics of 'Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense'. Together they form a unique fingerprint.

Cite this