Anti-epileptic drugs in migraine prevention

B. Lee Peterlin, Thomas N. Ward, Morris Levin

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


OBJECTIVE: Here we review the literature describing the efficacy and safety of 9 anti-epileptic drugs (AEDs) as migraine prophylaxis. Two of these agents are FDA-approved for this indication. SUMMARY: Several AEDs have demonstrated efficacy in migraine prophylaxis, including divalproex sodium, topiramate and, possibly, gabapentin. Many show encouraging results-even if not definitive. Future clinical trials may provide more evidence for using the newer AEDs in the prophylaxis of migraine.

Original languageEnglish (US)
Pages (from-to)18-36
Number of pages19
JournalHeadache and Pain: Diagnostic Challenges, Current Therapy
Issue number1
StatePublished - Dec 7 2005


  • Antiepileptic drugs
  • Carbamazepine
  • Divalproex sodium
  • Gabapentin
  • Lamotrigine
  • Levetiracetam
  • Migraine prophylaxis
  • Oxcarbazepine
  • Tiagabine
  • Topiramate
  • Zonisamide

ASJC Scopus subject areas

  • Clinical Neurology


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