TY - JOUR
T1 - Anti-cancer therapies of 21st century
T2 - Novel approach to treat human cancers using cold atmospheric plasma
AU - Ratovitski, Edward A.
AU - Cheng, Xiaoqian
AU - Yan, Dayun
AU - Sherman, Jonathan H.
AU - Canady, Jerome
AU - Trink, Barry
AU - Keidar, Michael
N1 - Publisher Copyright:
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2014/12/1
Y1 - 2014/12/1
N2 - Cold atmospheric plasma (CAP) has just recently been showing promising anti-cancer activities supported by ability to induce cell death via apoptosis and cell cycle arrest leading to tumor cell destruction in vitro, and in vivo. Several studies showed the ability of CAP-activated media to modulate the tumor cell environment a link between the generation of reactive oxygen species/reactive nitrogen species and cancer cell death following CAP treatment. Targeting cancer cells through ROS-mediated mechanisms has become an attractive strategy for effective and selective cancer treatment by exploiting the aberrant redox characteristics of cancer cells. These effects support the potential direct (CAP) and indirect (CAP-activated media) applications for adjuvant anti-cancer therapeutics, in a combination with the chemo-, radio-, and nano-therapies.
AB - Cold atmospheric plasma (CAP) has just recently been showing promising anti-cancer activities supported by ability to induce cell death via apoptosis and cell cycle arrest leading to tumor cell destruction in vitro, and in vivo. Several studies showed the ability of CAP-activated media to modulate the tumor cell environment a link between the generation of reactive oxygen species/reactive nitrogen species and cancer cell death following CAP treatment. Targeting cancer cells through ROS-mediated mechanisms has become an attractive strategy for effective and selective cancer treatment by exploiting the aberrant redox characteristics of cancer cells. These effects support the potential direct (CAP) and indirect (CAP-activated media) applications for adjuvant anti-cancer therapeutics, in a combination with the chemo-, radio-, and nano-therapies.
KW - Apoptosis
KW - Cancer
KW - Cell cycle arrest
KW - Cold atmospheric plasma
KW - Non-thermal plasma
KW - Reactive nitrogen species
KW - Reactive oxygen species
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U2 - 10.1002/ppap.201400071
DO - 10.1002/ppap.201400071
M3 - Review article
AN - SCOPUS:84916631784
SN - 1612-8850
VL - 11
SP - 1128
EP - 1137
JO - Plasma Processes and Polymers
JF - Plasma Processes and Polymers
IS - 12
ER -