Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles

N. Sanoj Rejinold; Reju George Thomas; Muthunarayanan Muthiah; K. P. Chennazhi; K. Manzoor; In Kyu Park; Yong Yeon Jeong; R. Jayakumar

doi:10.1016/j.ijbiomac.2014.11.044

Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles

N. Sanoj Rejinold
, Reju George Thomas
, Muthunarayanan Muthiah
, K. P. Chennazhi
, K. Manzoor
, In Kyu Park
, Yong Yeon Jeong
, R. Jayakumar

Research output: Contribution to journal › Article › peer-review

Abstract

The curcumin-encapsulated chitosan- graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) were developed by ionic cross-linking method. After "optimum RF exposure" at 40. W for 5. min, Au-CRC-TRC-NPs dissipated heat energy in the range of ~42. °C, the lower critical solution temperature (LCST) of chitosan- graft-poly(N-vinyl caprolactam), causing controlled curcumin release and apoptosis to cancer cells. Further, in vivo PK/PD studies on swiss albino mice revealed that Au-CRC-TRC-NPs could be sustained in circulation for a week with no harm to internal organs. The colon tumor localization studies revealed that Au-CRC-TRC-NPs were retained in tumor for a week. These results throw light on their feasibility as multi-responsive nanomedicine for RF-assisted cancer treatment modalities.

Original language	English (US)
Pages (from-to)	249-262
Number of pages	14
Journal	International Journal of Biological Macromolecules
Volume	74
DOIs	https://doi.org/10.1016/j.ijbiomac.2014.11.044
State	Published - Mar 1 2015
Externally published	Yes

Keywords

Chitosan-graft-PNVCL
Curcumin
Gold
RF therapy
Tumor localization

ASJC Scopus subject areas

Structural Biology
Biochemistry
Molecular Biology

Access to Document

10.1016/j.ijbiomac.2014.11.044

Cite this

@article{8c566a0f1b514990a39aae0e3f4df6af,

title = "Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles",

abstract = "The curcumin-encapsulated chitosan- graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) were developed by ionic cross-linking method. After {"}optimum RF exposure{"} at 40. W for 5. min, Au-CRC-TRC-NPs dissipated heat energy in the range of \textasciitilde{}42. °C, the lower critical solution temperature (LCST) of chitosan- graft-poly(N-vinyl caprolactam), causing controlled curcumin release and apoptosis to cancer cells. Further, in vivo PK/PD studies on swiss albino mice revealed that Au-CRC-TRC-NPs could be sustained in circulation for a week with no harm to internal organs. The colon tumor localization studies revealed that Au-CRC-TRC-NPs were retained in tumor for a week. These results throw light on their feasibility as multi-responsive nanomedicine for RF-assisted cancer treatment modalities.",

keywords = "Chitosan-graft-PNVCL, Curcumin, Gold, RF therapy, Tumor localization",

author = "\{Sanoj Rejinold\}, N. and Thomas, \{Reju George\} and Muthunarayanan Muthiah and Chennazhi, \{K. P.\} and K. Manzoor and Park, \{In Kyu\} and Jeong, \{Yong Yeon\} and R. Jayakumar",

note = "Publisher Copyright: {\textcopyright} 2014 Elsevier B.V.",

year = "2015",

month = mar,

day = "1",

doi = "10.1016/j.ijbiomac.2014.11.044",

language = "English (US)",

volume = "74",

pages = "249--262",

journal = "International Journal of Biological Macromolecules",

issn = "0141-8130",

publisher = "Elsevier B.V.",

}

TY - JOUR

T1 - Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles

AU - Sanoj Rejinold, N.

AU - Thomas, Reju George

AU - Muthiah, Muthunarayanan

AU - Chennazhi, K. P.

AU - Manzoor, K.

AU - Park, In Kyu

AU - Jeong, Yong Yeon

AU - Jayakumar, R.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - The curcumin-encapsulated chitosan- graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) were developed by ionic cross-linking method. After "optimum RF exposure" at 40. W for 5. min, Au-CRC-TRC-NPs dissipated heat energy in the range of ~42. °C, the lower critical solution temperature (LCST) of chitosan- graft-poly(N-vinyl caprolactam), causing controlled curcumin release and apoptosis to cancer cells. Further, in vivo PK/PD studies on swiss albino mice revealed that Au-CRC-TRC-NPs could be sustained in circulation for a week with no harm to internal organs. The colon tumor localization studies revealed that Au-CRC-TRC-NPs were retained in tumor for a week. These results throw light on their feasibility as multi-responsive nanomedicine for RF-assisted cancer treatment modalities.

AB - The curcumin-encapsulated chitosan- graft-poly(N-vinyl caprolactam) nanoparticles containing gold nanoparticles (Au-CRC-TRC-NPs) were developed by ionic cross-linking method. After "optimum RF exposure" at 40. W for 5. min, Au-CRC-TRC-NPs dissipated heat energy in the range of ~42. °C, the lower critical solution temperature (LCST) of chitosan- graft-poly(N-vinyl caprolactam), causing controlled curcumin release and apoptosis to cancer cells. Further, in vivo PK/PD studies on swiss albino mice revealed that Au-CRC-TRC-NPs could be sustained in circulation for a week with no harm to internal organs. The colon tumor localization studies revealed that Au-CRC-TRC-NPs were retained in tumor for a week. These results throw light on their feasibility as multi-responsive nanomedicine for RF-assisted cancer treatment modalities.

KW - Chitosan-graft-PNVCL

KW - Curcumin

KW - Gold

KW - RF therapy

KW - Tumor localization

UR - https://www.scopus.com/pages/publications/84920941136

UR - https://www.scopus.com/pages/publications/84920941136#tab=citedBy

U2 - 10.1016/j.ijbiomac.2014.11.044

DO - 10.1016/j.ijbiomac.2014.11.044

M3 - Article

C2 - 25526695

AN - SCOPUS:84920941136

SN - 0141-8130

VL - 74

SP - 249

EP - 262

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

ER -

Anti-cancer, pharmacokinetics and tumor localization studies of pH-, RF- and thermo-responsive nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this