Anti-β-endorphin immunoglobulin G in humans

B. F. Roy, J. W. Rose, H. F. McFarland, D. E. McFarlin, D. L. Murphy

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Human IgG specific for β-endorphin was identified by enzyme-linked immunoabsorbent assay and isolated by affinity chromatography. From a sample of 27 subjects, three individuals with major depression demonstrated plasma IgG highly reactive with human β-endorphin, while four other subjects (two with depression and two randomly selected blood donors) had intermediate reactivity. The recognition site for β-endorphin was retained by F(ab')2 fragments.

Original languageEnglish (US)
Pages (from-to)8739-8743
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number22
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • General


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