Abstract
Recent events have brought attention to the potential of Bacillus anthracis as an agent of bioterrorism. The shock like state of anthrax is invariably associated with high mortality, despite anti-microbial and supportive therapy. Multi-system dysfunction is typical, including: enhanced vascular permeability, hemorrhage and inflammation. Important questions concerning the pathophysiology of anthrax-associated shock remain unanswered, including the effects of B. anthracis infection on cardiac function. This review discusses the current state of knowledge regarding the pathophysiology of anthrax-associated shock.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4009-4014 |
| Number of pages | 6 |
| Journal | Frontiers in Bioscience |
| Volume | 13 |
| Issue number | 11 |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
Keywords
- Anthrax
- Bacillus anthracis
- Edema toxin
- Lethal toxin
- Review
- Shock
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)