TY - JOUR
T1 - Anterior-Posterior Guidance of Commissural Axons by Wnt-Frizzled Signaling
AU - Lyuksyutova, Anna I.
AU - Lu, Chin Chun
AU - Milanesio, Nancy
AU - King, Leslie A.
AU - Guo, Nini
AU - Wang, Yanshu
AU - Nathans, Jeremy
AU - Tessier-Lavigne, Marc
AU - Zou, Yimin
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/12/12
Y1 - 2003/12/12
N2 - Commissural neurons in the mammalian dorsal spinal cord send axons ventrally toward the floor plate, where they cross the midline and turn anteriorly toward the brain; a gradient of chemoattractant(s) inside the spinal cord controls this turning. In rodents, several Wnt proteins stimulate the extension of commissural axons after midline crossing (postcrossing). We found that Wnt4 messenger RNA is expressed in a decreasing anterior-to-posterior gradient in the floor plate, and that a directed source of Wnt4 protein attracted postcrossing commissural axons. Commissural axons in mice lacking the Wnt receptor Frizzled3 displayed anterior-posterior guidance defects after midline crossing. Thus, Wnt-Frizzled signaling guides commissural axons along the anterior-posterior axis of the spinal cord.
AB - Commissural neurons in the mammalian dorsal spinal cord send axons ventrally toward the floor plate, where they cross the midline and turn anteriorly toward the brain; a gradient of chemoattractant(s) inside the spinal cord controls this turning. In rodents, several Wnt proteins stimulate the extension of commissural axons after midline crossing (postcrossing). We found that Wnt4 messenger RNA is expressed in a decreasing anterior-to-posterior gradient in the floor plate, and that a directed source of Wnt4 protein attracted postcrossing commissural axons. Commissural axons in mice lacking the Wnt receptor Frizzled3 displayed anterior-posterior guidance defects after midline crossing. Thus, Wnt-Frizzled signaling guides commissural axons along the anterior-posterior axis of the spinal cord.
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U2 - 10.1126/science.1089610
DO - 10.1126/science.1089610
M3 - Article
C2 - 14671310
AN - SCOPUS:0348017150
SN - 0036-8075
VL - 302
SP - 1984
EP - 1988
JO - Science
JF - Science
IS - 5652
ER -