Abstract
OBJECTIVE: To determine whether changes in plasma levels of thrombomodulin from antepartum to postpartum reflect the postpartum regression of preeclampsia. METHODS: Twenty-four preeclamptic women and 34 healthy, normotensive women with singleton pregnancies were studied in the third trimester. Plasma levels of thrombomodulin in the antepartum and postpartum periods were measured by a two-site immunoenzymatic assay. Two- tailed Student t test and paired-comparison t test were used for statistical analyses. The results were expressed as mean ± standard error. RESULTS: Antepartum plasma thrombomodulin levels in preeclampsia were significantly higher than postpartum levels (71.3 ± 8.5 versus 55.5 ± 5.4 ng/mL; P = .006), which was not seen in the normotensive controls (49.9 ± 3.1 versus 44.2 ± 3.8 ng/mL; P > .05). Antepartum plasma levels of thrombomodulin in preeclampsia women were significantly higher than those in the normotensive controls (P = .01). However, postpartum plasma levels of thrombomodulin in preeclamptic women were not significantly higher than those in the normotensive controls (P > .05). CONCLUSION: Significantly decreased postpartum plasma thrombomodulin levels in preeclamptic pregnancies strongly correspond to clinical postpartum regression of preeclampsia.
Original language | English (US) |
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Pages (from-to) | 135-137 |
Number of pages | 3 |
Journal | Journal of the Society for Gynecologic Investigation |
Volume | 4 |
Issue number | 3 |
DOIs | |
State | Published - May 1997 |
Externally published | Yes |
Keywords
- Antepartum
- Postpartum
- Preeclampsia
- Thrombomodulin
ASJC Scopus subject areas
- Obstetrics and Gynecology